Is Conservative Management of Noninvasive Follicular Thyroid Neoplasm With Papillary-Like Nuclear Features (NIFTP) Possible in Children?

IF 1.3 4区医学 Q3 PATHOLOGY Pediatric and Developmental Pathology Pub Date : 2024-09-25 DOI:10.1177/10935266241282055

Ulgen Celtik, Yesim Ertan, Samim Ozen, Damla Goksen, Ahmet Celik

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Abstract

Background: Noninvasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP) is a newly recognized entity with benign clinical characteristics. We aim to compare NIFTP with invasive encapsulated follicular variant papillary carcinoma (fvPTC) and to discuss the management.

Methods: Records of patients with fvPTC and NIFTP between 2016 and 2022 were reviewed retrospectively. Two groups were compared according to demographics, surgical management, postoperative management, and long-term follow-up.

Results: Twenty patients were included in the study, with 10 in NIFTP group and 10 in fvPTC group. The mean age at operation was 14.10 ± 2.61 years. Demographics and preoperative nodule sizes (P = .912) were statistically similar between the 2 groups. Although lobectomy was more common in the NIFTP group, this difference was not statistically significant compared to the fvPTC group in terms of surgical treatment. Postoperatively, while no patient received radioactive iodine treatment(RAI) in NIFTP group, 6 patients in fvPTC group did (P = .011). Five patients in NIFTP group and 3 in the fvPTC group were followed up with lobectomy only, without any adverse events or recurrence, for 47.50 ± 19.25 and 30.10 ± 19.25 months, respectively.

Conclusion: In conclusion, NIFTP appears to be an indolent disease in children. Therefore, observation with lobectomy is sufficient, and RAI is not necessary.

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儿童是否可能接受具有乳头状核特征的非侵袭性滤泡性甲状腺肿瘤 (NIFTP) 的保守治疗？

背景：具有乳头状核特征的非侵袭性滤泡性甲状腺肿瘤（NIFTP）是一种新近被发现的具有良性临床特征的实体瘤。我们旨在比较NIFTP与浸润性包膜滤泡样乳头状癌（fvPTC），并讨论其治疗方法：方法：回顾性审查了2016年至2022年间fvPTC和NIFTP患者的记录。根据人口统计学、手术处理、术后处理和长期随访情况对两组患者进行比较：研究共纳入20例患者，其中NIFTP组10例，fvPTC组10例。手术时的平均年龄为（14.10 ± 2.61）岁。两组患者的人口统计学和术前结节大小（P = .912）在统计学上相似。虽然 NIFTP 组患者更常接受肺叶切除术，但在手术治疗方面，与 fvPTC 组相比，差异无统计学意义。术后，NIFTP 组没有患者接受放射性碘治疗（RAI），而 fvPTC 组有 6 名患者接受了放射性碘治疗（P = .011）。NIFTP 组的 5 名患者和 fvPTC 组的 3 名患者仅接受了肺叶切除术，分别随访了 47.50 ± 19.25 个月和 30.10 ± 19.25 个月，未发生任何不良事件或复发：总之，NIFTP 在儿童中似乎是一种隐匿性疾病。因此，通过肺叶切除术进行观察就足够了，并不需要 RAI。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Pediatric and Developmental Pathology 医学-病理学

CiteScore

3.70

自引率

5.30%

发文量

审稿时长

6-12 weeks

期刊介绍： The Journal covers the spectrum of disorders of early development (including embryology, placentology, and teratology), gestational and perinatal diseases, and all diseases of childhood. Studies may be in any field of experimental, anatomic, or clinical pathology, including molecular pathology. Case reports are published only if they provide new insights into disease mechanisms or new information.