Third Trimester Stillbirth Associated With Hamartoma of Mature Cardiac Myocytes (HMCM).

IF 1.3 4区 医学 Q3 PATHOLOGY Pediatric and Developmental Pathology Pub Date : 2024-09-28 DOI:10.1177/10935266241286716
Silvia Planas, Mariona Genero, Miriam Illa
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Abstract

Fetal primary cardiac tumors (FPCTs) are very rare. The majority of them correspond to cardiac rhabdomyomas, followed by other benign neoplasms or hamartomas. We describe the case of a third trimester female stillborn with an incidental autopsy finding of Hamartoma of Mature Cardiac Myocytes (HMCM), a rare benign cardiac tumor previously unreported in the fetal or neonatal period. The intrauterine demise occurred at 32 + 6 weeks gestation after an uneventful pregnancy. The fetal autopsy revealed a structurally normal heart with a small subendocardial nodule just below the membranous septum. Microscopically, the nodule was well-demarcated from the surrounding penetrating bundle of the conduction axis and the adjacent left ventricular myocardium and consisted of disorganized mature cardiac myocytes in a haphazard arrangement with patchy mild interstitial fibrosis, consistent with HMCM. Awareness that HMCM can occur in the fetus is important in order to consider it among the differential diagnosis of FPCTs.

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与成熟心肌细胞脂肪瘤(HMCM)相关的第三胎死产。
胎儿原发性心脏肿瘤(FPCT)非常罕见。其中大多数是心脏横纹肌瘤,其次是其他良性肿瘤或火腿肠瘤。我们描述了一例怀孕三个月的女死胎,尸检意外发现其患有成熟心肌细胞火腿状瘤(HMCM),这是一种罕见的良性心脏肿瘤,以前从未在胎儿或新生儿期报道过。胎儿在妊娠 32+6 周时夭折,此前妊娠过程并不顺利。胎儿尸检显示心脏结构正常,在膜隔下方有一个心内膜下小结节。显微镜下,该结节与周围的传导轴穿透束和邻近的左心室心肌分界清晰,由杂乱无章的成熟心肌细胞组成,伴有斑片状轻度间质纤维化,与 HMCM 一致。认识到 HMCM 可发生在胎儿身上非常重要,以便将其作为 FPCT 的鉴别诊断之一。
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来源期刊
CiteScore
3.70
自引率
5.30%
发文量
59
审稿时长
6-12 weeks
期刊介绍: The Journal covers the spectrum of disorders of early development (including embryology, placentology, and teratology), gestational and perinatal diseases, and all diseases of childhood. Studies may be in any field of experimental, anatomic, or clinical pathology, including molecular pathology. Case reports are published only if they provide new insights into disease mechanisms or new information.
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