Metastatic Medullary Thyroid Carcinoma Presenting as an Incidental Posterior Mediastinal Mass.

IF 1.2 4区 医学 Q4 CELL BIOLOGY Cytopathology Pub Date : 2024-09-27 DOI:10.1111/cyt.13449
Chaya Goldberg, DeAnna Diaz, Tamar Brandler
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Abstract

Medullary thyroid carcinoma (MTC) is an uncommon neuroendocrine tumour that is usually asymptomatic at its onset and therefore may not present clinically until the patient has developed advanced or metastatic disease. Common metastatic sites include cervical lymph nodes, liver, bone and lung. This is the case of a patient who presented with an incidental posterior mediastinal mass. Because the posterior mediastinum is an unusual location for MTC, MTC was not a consideration and preliminary histopathological testing did not include calcitonin, which would have been diagnostic. This case highlights the importance of testing for calcitonin more regularly when encountering a mass of unknown origin with neuroendocrine morphology, which may lead to earlier detection of MTC and thus improved prognosis.

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转移性甲状腺髓样癌偶见纵隔后肿块
甲状腺髓样癌(MTC)是一种不常见的神经内分泌肿瘤,发病时通常没有症状,因此可能直到患者出现晚期或转移性疾病时才会出现临床表现。常见的转移部位包括颈淋巴结、肝、骨和肺。本病例是一名偶然发现后纵隔肿块的患者。由于后纵隔是 MTC 的一个不常见部位,因此 MTC 并不在考虑之列,而且初步组织病理学检测也未包括降钙素,而降钙素本应具有诊断意义。本病例强调了在遇到来源不明的神经内分泌形态肿块时,定期检测降钙素的重要性,这可能会导致更早地发现 MTC,从而改善预后。
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来源期刊
Cytopathology
Cytopathology 生物-病理学
CiteScore
2.30
自引率
15.40%
发文量
107
审稿时长
6-12 weeks
期刊介绍: The aim of Cytopathology is to publish articles relating to those aspects of cytology which will increase our knowledge and understanding of the aetiology, diagnosis and management of human disease. It contains original articles and critical reviews on all aspects of clinical cytology in its broadest sense, including: gynaecological and non-gynaecological cytology; fine needle aspiration and screening strategy. Cytopathology welcomes papers and articles on: ultrastructural, histochemical and immunocytochemical studies of the cell; quantitative cytology and DNA hybridization as applied to cytological material.
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