Treatment of High-Risk Gestational Trophoblastic Neoplasia

IF 2.5 3区 医学 Q2 HEMATOLOGY Hematology-Oncology Clinics of North America Pub Date : 2024-09-24 DOI:10.1016/j.hoc.2024.08.014
Antonio Braga MD, PhD , Gabriela Paiva MD , Raphael Alevato MD , Penélope Saldanha MD, PhD , Kevin M. Elias MD , Neil S. Horowitz MD , Ross S. Berkowitz MD
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治疗高风险妊娠滋养细胞肿瘤。
高危妊娠滋养细胞肿瘤包括疾病体积大或弥漫转移受累的患者,他们不太可能通过单药化疗获得缓解。以依托泊苷为基础的多药方案是高危治疗的核心。二线疗法包括以铂为基础的方案。三线疗法越来越多地采用免疫疗法。切除耐药病灶或处理并发症可能需要手术干预。治疗应持续到 hCG 低于正常参考范围,然后进行至少 3 个周期的巩固治疗。对于大多数需要接受多药治疗的患者来说,最好至少进行 2 年的 hCG 监测,以覆盖 95% 的复发率。
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来源期刊
CiteScore
4.10
自引率
0.00%
发文量
86
审稿时长
6-12 weeks
期刊介绍: Hematology/Oncology Clinics updates you on the latest trends in patient management, keeps you up to date on the newest advances, and provides a sound basis for choosing treatment options. Under the direction of an experienced guest editor, each issue focuses on a single topic in hematology and oncology, including hemostasis and thrombosis, molecular and cellular basis of hematology, coagulation disorders, and cancers—bone, gastrointestinal, head and neck, lymphomas, neuroendocrine, breast, renal cell, melanoma, and more.
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