Neonatal gut microbiota profile and the association with retinopathy of prematurity in preterm infants.

IF 4.9 2区 医学 Q1 OPHTHALMOLOGY Clinical and Experimental Ophthalmology Pub Date : 2024-09-25 DOI:10.1111/ceo.14441
Yin-Hsi Chang, Yuan-Ming Yeh, Chien-Chung Lee, Cheng-Hsun Chiu, Hung-Chi Chen, Yi-Jen Hsueh, Chia-Wen Lee, Reyin Lien, Shih-Ming Chu, Ming-Chou Chiang, Eugene Yu-Chuan Kang, Kuan-Jen Chen, Nan-Kai Wang, Laura Liu, Yih-Shiou Hwang, Chi-Chun Lai, Wei-Chi Wu
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Abstract

Background: To explore the role of gut microbiota in preterm infants at high risk of developing retinopathy of prematurity (ROP).

Methods: Preterm infants with gestational age (GA) < 32 weeks and/or birth weight (BW) < 1500 g born between 2020 and 2021 were prospectively enrolled. Their faecal samples were collected and analysed at different postnatal ages of life using 16S rRNA gene sequencing on the Miseq platform. The main outcome measures were the microbial diversity, taxonomy, relative abundance, bacterial predicted functional analysis, and their associations with different ROP groups. Subgroup analyses were performed by matching their GA and BW across different ROP groups.

Results: A total of 268 stool samples were collected from 110 preterm infants, including 13 with type 1 ROP, 44 with type 2 or mild ROP, and 53 without ROP. Type 1 ROP showed no significant difference in microbial diversity up to 8 postnatal weeks (p = 0.057), while type 2 and no ROP groups displayed increased diversity (p = 0.0015 and p = 0.049, respectively). Bifidobacterium genera was notably less abundant in type 1 ROP group at first postnatal week (p = 0.022) and remained low in subsequent weeks. Predicted functional analysis revealed enriched pathways in membrane transport, carbohydrate metabolism, amino acid metabolism, and replication and repair.

Conclusions: Reduced gut microbial diversity may be associated with ROP development in high-risk preterm infants. Further research is needed to comprehend how early-life Bifidobacterium reduction affects metabolism and how targeting microbiome may help for ROP prevention and management.

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新生儿肠道微生物群谱及与早产儿视网膜病变的关系。
背景:探讨肠道微生物群在早产儿视网膜病变高风险人群中的作用:探讨肠道微生物群在早产儿视网膜病变(ROP)高风险人群中的作用:结果:110 名胎龄(GA)早产儿共采集了 268 份粪便样本:共收集了 110 名早产儿的 268 份粪便样本,其中 13 名患有 1 型早产儿视网膜病变,44 名患有 2 型或轻度早产儿视网膜病变,53 名未患有早产儿视网膜病变。1 型 ROP 在出生后 8 周内的微生物多样性无明显差异(p = 0.057),而 2 型和无 ROP 组的微生物多样性有所增加(分别为 p = 0.0015 和 p = 0.049)。在出生后第一周,1 型 ROP 组中双歧杆菌属的数量明显较少(p = 0.022),并且在随后的几周中仍然较少。预测功能分析显示,膜转运、碳水化合物代谢、氨基酸代谢以及复制和修复的途径丰富:结论:肠道微生物多样性的降低可能与高风险早产儿发生视网膜病变有关。结论:肠道微生物多样性的减少可能与高风险早产儿的视网膜病变有关。还需要进一步研究,以了解生命早期双歧杆菌的减少如何影响新陈代谢,以及针对微生物组的研究如何有助于视网膜病变的预防和管理。
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来源期刊
CiteScore
7.60
自引率
12.50%
发文量
150
审稿时长
4-8 weeks
期刊介绍: Clinical & Experimental Ophthalmology is the official journal of The Royal Australian and New Zealand College of Ophthalmologists. The journal publishes peer-reviewed original research and reviews dealing with all aspects of clinical practice and research which are international in scope and application. CEO recognises the importance of collaborative research and welcomes papers that have a direct influence on ophthalmic practice but are not unique to ophthalmology.
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