Appropriate dose of tranexamic acid in the topical treatment of anterior epistaxis, 500 mg vs 1000 mg: A double-blind randomized controlled trial.

IF 2.6 4区 综合性期刊 Q2 MULTIDISCIPLINARY SCIENCES Science Progress Pub Date : 2024-10-01 DOI:10.1177/00368504241264993
Cüneyt Arikan, Pınar Yeşim Akyol
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Abstract

Aims: Patients with epistaxis typically visit the emergency department for initial treatment. According to recent studies, tranexamic acid (TXA) is effective in the treatment of epistaxis. This study compared the therapeutic superiority of saline to that of 500 and 1000 mg doses of topical TXA for the treatment of anterior epistaxis. Materials and methods: This phase 4 clinical trial was a randomized, controlled, and double-blind trial. A total of 152 patients were divided into three groups. Group 1 was treated with 1000 mg TXA, Group 2 with 500 mg TXA, and Group 3 with saline. Results: Based on multinomial logistic regression analysis, the bleeding frequency at the 5th minute was 2.9 times and rebleeding status was 4.3 times less in Group 1 (1000 mg TXA) than in Group 3 (saline). There were no differences between the three groups in terms of side effects or salvage therapy. Conclusion: In addition to its superiority in treatment, 1000 mg of TXA is recommended because of the decreased rate of recurrent bleeding and low incidence of side effects.

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氨甲环酸局部治疗前鼻衄的适当剂量:500 毫克与 1000 毫克:双盲随机对照试验。
目的:鼻衄患者通常会到急诊科接受初步治疗。根据最近的研究,氨甲环酸(TXA)可有效治疗鼻衄。本研究比较了生理盐水与 500 毫克和 1000 毫克剂量的局部氨甲环酸治疗前鼻衄的疗效优劣。材料和方法:这项 4 期临床试验是一项随机、对照和双盲试验。共有 152 名患者被分为三组。第一组使用 1000 毫克 TXA,第二组使用 500 毫克 TXA,第三组使用生理盐水。结果根据多项式逻辑回归分析,第 1 组(1000 毫克 TXA)在第 5 分钟的出血频率是第 3 组(生理盐水)的 2.9 倍,再出血情况是第 3 组(生理盐水)的 4.3 倍。三组在副作用和挽救治疗方面没有差异。结论1000 毫克 TXA 除了在治疗方面具有优势外,还因其降低了复发出血率和副作用发生率而受到推荐。
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来源期刊
Science Progress
Science Progress Multidisciplinary-Multidisciplinary
CiteScore
3.80
自引率
0.00%
发文量
119
期刊介绍: Science Progress has for over 100 years been a highly regarded review publication in science, technology and medicine. Its objective is to excite the readers'' interest in areas with which they may not be fully familiar but which could facilitate their interest, or even activity, in a cognate field.
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