Viral etiologies of acute liver failure.

Brian W McSteen, Xiao-Han Ying, Catherine Lucero, Arun B Jesudian
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Abstract

Acute liver failure (ALF) is a rare cause of liver-related mortality worldwide, with an estimated annual global incidence of more than one million cases. While drug-induced liver injury, including acetaminophen toxicity, is the leading cause of ALF in the Western world, viral infections remain a significant cause of ALF and the most common cause in many developing nations. Given the high mortality rates associated with ALF, healthcare providers should be aware of the broad range of viral infections that have been implicated to enable early diagnosis, rapid treatment initiation when possible, and optimal management, which may include liver transplantation. This review aims to provide a summary of viral causes of ALF, diagnostic approaches, treatment options, and expected outcomes.

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急性肝衰竭的病毒病因。
急性肝衰竭(ALF)是全球罕见的肝脏相关死亡病因,估计全球年发病率超过 100 万例。在西方国家,药物引起的肝损伤(包括对乙酰氨基酚中毒)是导致急性肝衰竭的主要原因,而病毒感染仍然是导致急性肝衰竭的重要原因,也是许多发展中国家最常见的原因。鉴于与 ALF 相关的高死亡率,医疗服务提供者应了解与之相关的各种病毒感染,以便及早诊断、在可能的情况下迅速开始治疗并进行最佳管理,其中可能包括肝移植。本综述旨在概述导致 ALF 的病毒病因、诊断方法、治疗方案和预期结果。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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