Secukinumab Causing Medication-Related Osteonecrosis of the Jaw, in a Patient Diagnosed with Psoriasis and Rheumatoid Arthritis.

IF 5.2 Q1 DERMATOLOGY Psoriasis (Auckland, N.Z.) Pub Date : 2024-09-23 eCollection Date: 2024-01-01 DOI:10.2147/PTT.S490982
Lukas Hauer, Omid Moztarzadeh, Nasimeh Baghalipour, Jiri Gencur
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Abstract

The use of antiangiogenic and antiresorptive medications, particularly in patients with cancer or osteoporosis, can lead to osteonecrosis of the jaw following tooth extraction, trauma or arising spontaneously- A condition known as medication-related osteonecrosis of the jaw (MRONJ). In this article, we present a unique case of MRONJ in a patient with no history of antiresorptive or antiangiogenic drug use, who was instead taking the anti-interleukin 17-A (Secukinumab) medication for severe psoriasis. This association has not been previously reported in the literature.

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塞库单抗在一名确诊为银屑病和类风湿性关节炎的患者中引发药物相关性颌骨坏死。
抗血管生成和抗骨吸收药物的使用,尤其是癌症或骨质疏松症患者,可能会在拔牙、外伤或自发后导致颌骨骨坏死--这种情况被称为药物相关性颌骨骨坏死(MRONJ)。在本文中,我们介绍了一例独特的MRONJ病例,该患者无抗骨吸收或抗血管生成药物使用史,而是在服用抗白细胞介素17-A(塞库单抗)药物治疗严重的银屑病。这种关联以前从未在文献中报道过。
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期刊最新文献
Impact of GLP-1 Receptor Agonists on Psoriasis and Cardiovascular Comorbidities: A Narrative Review. A New Prescription Emollient Device (PED) For Psoriasis of Sensitive Areas and Folds: A Randomized Prospective Open Trial. Psoriasis Flare Following Paramyxovirus Infection. Metabolic Syndrome in Psoriasis and Psoriatic Arthritis in a Mixed Race Population: Comparison of Their Prevalences. Do NSAIDs Trigger or Exacerbate Psoriasis? [Response to Letter].
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