The tumor microenvironment's gambit: Exosomal pawns on the board of head and neck cancer

IF 11.3 1区化学 Q1 CHEMISTRY, PHYSICAL ACS Catalysis Pub Date : 2024-09-27 DOI:10.1016/j.bbcan.2024.189189

Solmaz Mohamadi , Parisa Mehrasa , Bahareh Mehramuz , Sepehr Kobravi , Mohammad Taghizadieh , Arash Salmaninejad , Mobina Bayat , Javid Sadri Nahand

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Abstract

The tumor microenvironment (TME) harbors a hidden universe of interactions that profoundly shape the behavior of head and neck cancers (HNCs). HNCs are not merely localized afflictions; they constitute a pressing global health crisis that impacts millions, frequently resulting in severe prognoses due to late-stage diagnosis and intrinsic resistance to conventional therapies. In this intricate interplay, cancer cells function as strategic players, adeptly manipulating their microenvironment to foster proliferation, evade immune detection, and withstand therapeutic interventions. Central to this dynamic play are exosomes, the enigmatic pawns of cellular communication, carrying vital messages across the board. This review elucidates the multifaceted roles of exosomes within the TME, highlighting their capacity to transmit critical signals that not only promote tumor progression but also modulate immune responses, ultimately playing a crucial role in the evolving narrative of HNC. Our insights aim to catalyze further research and exploration into exosome-targeted therapies, potentially transforming the landscape of HNC treatment and improving clinical outcomes in this formidable battle against cancer.

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肿瘤微环境的赌局：头颈癌棋盘上的外泌体棋子

肿瘤微环境（TME）隐藏着各种相互作用，深刻影响着头颈部癌症（HNCs）的行为。HNCs 不仅仅是局部性疾病，它们还构成了影响数百万人的紧迫的全球健康危机，由于晚期诊断和对传统疗法的内在抵抗力，常常导致严重的预后。在这种错综复杂的相互作用中，癌细胞作为战略参与者，善于操纵其微环境以促进增殖、逃避免疫检测并抵御治疗干预。外泌体是这一动态游戏的核心，它是细胞通信的神秘棋子，全面传递着重要信息。这篇综述阐明了外泌体在TME中的多方面作用，强调了它们传递关键信号的能力，这些信号不仅能促进肿瘤进展，还能调节免疫反应，最终在不断演变的HNC叙述中发挥关键作用。我们的见解旨在促进对外泌体靶向疗法的进一步研究和探索，从而有可能改变 HNC 治疗的格局，改善这场艰巨的抗癌战役的临床结果。

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来源期刊

ACS Catalysis CHEMISTRY, PHYSICAL-

CiteScore

20.80

自引率

6.20%

发文量

1253

审稿时长

1.5 months

期刊介绍： ACS Catalysis is an esteemed journal that publishes original research in the fields of heterogeneous catalysis, molecular catalysis, and biocatalysis. It offers broad coverage across diverse areas such as life sciences, organometallics and synthesis, photochemistry and electrochemistry, drug discovery and synthesis, materials science, environmental protection, polymer discovery and synthesis, and energy and fuels. The scope of the journal is to showcase innovative work in various aspects of catalysis. This includes new reactions and novel synthetic approaches utilizing known catalysts, the discovery or modification of new catalysts, elucidation of catalytic mechanisms through cutting-edge investigations, practical enhancements of existing processes, as well as conceptual advances in the field. Contributions to ACS Catalysis can encompass both experimental and theoretical research focused on catalytic molecules, macromolecules, and materials that exhibit catalytic turnover.