Federico Rebaudi , Fabiana De Franco , Rayan Goda , Valentina Obino , Giorgio Vita , Camilla Baronti , Eleonora Iannone , Francesca Pitto , Barbara Massa , Daniela Fenoglio , Camilla Jandus , Francesca Poggio , Piero Fregatti , Ombretta Melaiu , Matteo Bozzo , Simona Candiani , Federica Papaccio , Marco Greppi , Silvia Pesce , Emanuela Marcenaro
{"title":"The landscape of combining immune checkpoint inhibitors with novel Therapies: Secret alliances against breast cancer","authors":"Federico Rebaudi , Fabiana De Franco , Rayan Goda , Valentina Obino , Giorgio Vita , Camilla Baronti , Eleonora Iannone , Francesca Pitto , Barbara Massa , Daniela Fenoglio , Camilla Jandus , Francesca Poggio , Piero Fregatti , Ombretta Melaiu , Matteo Bozzo , Simona Candiani , Federica Papaccio , Marco Greppi , Silvia Pesce , Emanuela Marcenaro","doi":"10.1016/j.ctrv.2024.102831","DOIUrl":null,"url":null,"abstract":"<div><div>This review focuses on the immune checkpoint inhibitors (ICIs) in the context of breast cancer (BC) management. These innovative treatments, by targeting proteins expressed on both tumor and immune cells, aim to overcome tumor-induced immune suppression and reactivate the immune system. The potential of this approach is the subject of numerous clinical studies. Here, we explore the key studies and emerging therapies related to ICIs providing a detailed analysis of their specific and combined use in BC treatment.</div></div>","PeriodicalId":9537,"journal":{"name":"Cancer treatment reviews","volume":"130 ","pages":"Article 102831"},"PeriodicalIF":9.6000,"publicationDate":"2024-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Cancer treatment reviews","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0305737224001592","RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"ONCOLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
This review focuses on the immune checkpoint inhibitors (ICIs) in the context of breast cancer (BC) management. These innovative treatments, by targeting proteins expressed on both tumor and immune cells, aim to overcome tumor-induced immune suppression and reactivate the immune system. The potential of this approach is the subject of numerous clinical studies. Here, we explore the key studies and emerging therapies related to ICIs providing a detailed analysis of their specific and combined use in BC treatment.
期刊介绍：
Cancer Treatment Reviews
Journal Overview:
International journal focused on developments in cancer treatment research
Publishes state-of-the-art, authoritative reviews to keep clinicians and researchers informed
Regular Sections in Each Issue:
Comments on Controversy
Tumor Reviews
Anti-tumor Treatments
New Drugs
Complications of Treatment
General and Supportive Care
Laboratory/Clinic Interface
Submission and Editorial System:
Online submission and editorial system for Cancer Treatment Reviews
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