An Alternative Diagnostic Test rather than 24 hours Urinary Protein to Detect Massive Proteinuria in Nephrotic Syndrome in Mymensingh Medical College Hospital, Bangladesh.

Mymensingh medical journal : MMJ Pub Date : 2024-10-01
F Akhter, M A Hoque, M N Islam, M Akhtaruzzaman, B Chowdhury, M J Hussain, S E Amin, S S Sultana, K Begum
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Abstract

This cross-sectional study was conducted in Department of Paediatrics, Mymensingh Medical College Hospital (MMCH), Bangladesh from February 2016 to December 2016 to detect massive proteinuria by spot urinary protein creatinine ratio as an alternative diagnostic test to 24 hrs urinary total protein in nephrotic syndrome. Fifty one (51) children aged 2 to 12 years admitted with 1st episode of nephrotic syndrome in the pediatric department of MMCH were included in this by purposive sampling technique. All the patients were asked to give a 24 hours urine sample. After this collection the next spot urine samples were collected for protein and creatinine estimation. Among 51 patients 33 were male and 18 were female. The mean age was 5.5+2.3 years. The entire patient had normal renal function. The mean 24 hours urinary protein level was 3.8±1.7 gm/m²/24 hours, the mean spot urinary protein-creatinine ratio was 5.4±2.5. Mean serum albumin was 1.8±0.6 gm/dl and the mean serum cholesterol was 357.6±74.7 mg/dl. The spot urinary protein creatinine ratio was increased with the increase in the amount of 24 hours urinary total protein and a strong positive Pearson correlation (r=0.805) was found. In all the cases of nephrotic syndrome spot urinary protein creatinine ratio were found more than 2. Based on this study, it can be concluded that the determination of the spot urinary protein-creatinine ratio can replace the 24 hours urine collection in the quantitation of proteinuria in nephrotic syndrome.

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孟加拉迈门辛医学院医院检测肾病综合征大量蛋白尿的另一种诊断测试,而非 24 小时尿蛋白。
这项横断面研究于2016年2月至2016年12月在孟加拉国迈门辛医学院医院(MMCH)儿科进行,旨在通过定点尿蛋白肌酐比值检测大量蛋白尿,作为肾病综合征24小时尿总蛋白的替代诊断测试。通过目的性抽样技术,51 名 2 至 12 岁首次患肾病综合征的儿童被纳入 MMCH 儿科。所有患者都被要求提供 24 小时尿液样本。采集尿样后,再采集下一个点的尿样以估算蛋白质和肌酐。51 名患者中有 33 名男性和 18 名女性。平均年龄为 5.5+2.3 岁。所有患者的肾功能均正常。平均 24 小时尿蛋白水平为 3.8±1.7 克/平方米/24 小时,平均定点尿蛋白-肌酐比值为 5.4±2.5。平均血清白蛋白为 1.8±0.6 克/分升,平均血清胆固醇为 357.6±74.7 毫克/分升。定点尿蛋白肌酐比值随 24 小时尿总蛋白量的增加而增加,并发现两者之间存在很强的正相关性(r=0.805)。所有肾病综合征病例的定点尿蛋白肌酐比值均大于 2。 根据这项研究,可以得出结论,定点尿蛋白肌酐比值的测定可以取代 24 小时尿收集,用于肾病综合征蛋白尿的定量分析。
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