The expression and clinical significance of cytokines Th1, Th2, and Th17 in ovarian cancer.

Chibo Liu, Dongguo Wang, Xingtang Huang, Zhiwei Song, Liuqing Ye, Guoming Zhou
{"title":"The expression and clinical significance of cytokines Th1, Th2, and Th17 in ovarian cancer.","authors":"Chibo Liu, Dongguo Wang, Xingtang Huang, Zhiwei Song, Liuqing Ye, Guoming Zhou","doi":"10.1016/j.amjms.2024.08.029","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>This study was to analyze the levels of Th1, Th2 and Th17 cytokines in peripheral blood samples from ovarian cancer (OC) patients.</p><p><strong>Methods: </strong>Ninty-five OC patients including 45 OC and 50 benign ovarian disease (BOD) were selected at Zhejiang Cancer Hospital from October 2021 to March 2022; 46 healthy participants were simultaneously selected at Taizhou Municipal Hospital as healthy controls (HC). The expressions of Th1, Th2 and Th17 were compared in all participants. Marker levels were analyzed with age, histological type, tumor size, ovarian number and clinical stage of OC.</p><p><strong>Results: </strong>The IL6 and IL8 levels were significantly higher in OC compared to BOD and HC (p < 0.00). The IL-4 expression was significantly higher in OC compared to HC (p < 0.00). The expressions of IL2, IL6 and IL10 were significantly higher in pathological stage III-IV OC compared with pathological stage I-II OC (p < 0.05). Meanwhile, the levels of IL-2 and IL-10 were significantly higher in OC with bilateral ovaries than in OC with single ovary (p < 0.05). AUCs of different markers were to diagnose OC. The findings also implied that the expressions of IL-6, IL-8 and IL-10 were significantly different between OC and control groups (p < 0.05), while the levels of IL-2, IL-4, TNF-α, IFN-γ, IL-12p70, IL-1β and IL-5 between the two groups were not different (p > 0.05).</p><p><strong>Conclusions: </strong>In peripheral blood from OC patients, the immune system was more dysregulated and immune cells produced more cytokines with contrasting actions. These data showed significant clinical implications for the diagnosis of OC.</p>","PeriodicalId":94223,"journal":{"name":"The American journal of the medical sciences","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2024-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"The American journal of the medical sciences","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1016/j.amjms.2024.08.029","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0

Abstract

Background: This study was to analyze the levels of Th1, Th2 and Th17 cytokines in peripheral blood samples from ovarian cancer (OC) patients.

Methods: Ninty-five OC patients including 45 OC and 50 benign ovarian disease (BOD) were selected at Zhejiang Cancer Hospital from October 2021 to March 2022; 46 healthy participants were simultaneously selected at Taizhou Municipal Hospital as healthy controls (HC). The expressions of Th1, Th2 and Th17 were compared in all participants. Marker levels were analyzed with age, histological type, tumor size, ovarian number and clinical stage of OC.

Results: The IL6 and IL8 levels were significantly higher in OC compared to BOD and HC (p < 0.00). The IL-4 expression was significantly higher in OC compared to HC (p < 0.00). The expressions of IL2, IL6 and IL10 were significantly higher in pathological stage III-IV OC compared with pathological stage I-II OC (p < 0.05). Meanwhile, the levels of IL-2 and IL-10 were significantly higher in OC with bilateral ovaries than in OC with single ovary (p < 0.05). AUCs of different markers were to diagnose OC. The findings also implied that the expressions of IL-6, IL-8 and IL-10 were significantly different between OC and control groups (p < 0.05), while the levels of IL-2, IL-4, TNF-α, IFN-γ, IL-12p70, IL-1β and IL-5 between the two groups were not different (p > 0.05).

Conclusions: In peripheral blood from OC patients, the immune system was more dysregulated and immune cells produced more cytokines with contrasting actions. These data showed significant clinical implications for the diagnosis of OC.

查看原文
分享 分享
微信好友 朋友圈 QQ好友 复制链接
本刊更多论文
细胞因子 Th1、Th2 和 Th17 在卵巢癌中的表达及其临床意义。
背景:本研究旨在分析卵巢癌(OC)患者外周血样本中 Th1、Th2 和 Th17 细胞因子的水平:本研究旨在分析卵巢癌(OC)患者外周血样本中Th1、Th2和Th17细胞因子的水平:方法:选取2021年10月至2022年3月浙江省肿瘤医院收治的95例卵巢癌患者作为研究对象,其中包括45例卵巢癌患者和50例良性卵巢病(BOD)患者;同时选取台州市立医院收治的46例健康人作为健康对照(HC)。比较了所有参与者中 Th1、Th2 和 Th17 的表达。标记物水平与OC的年龄、组织学类型、肿瘤大小、卵巢数量和临床分期有关:结果:与 BOD 和 HC 相比,OC 的 IL6 和 IL8 水平明显更高(P 0.05):结论:在 OC 患者的外周血中,免疫系统更加失调,免疫细胞产生了更多具有相反作用的细胞因子。这些数据对 OC 的诊断具有重要的临床意义。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 去求助
来源期刊
自引率
0.00%
发文量
0
期刊最新文献
Utility of arterial to end-tidal carbon dioxide gradient as a severity index in critical care. Challenges in multimodal chronic pain management in primary care settings. Racial disparities exist in utilization of catheter ablation for atrial fibrillation in the United States. An observational study of the causes of an isolated elevated alkaline phosphatase level of unclear etiology. Carcinoma Erysipeloides, A Case-report and Review of the Sixty-nine Cases in the Literature.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
已复制链接
已复制链接
快去分享给好友吧!
我知道了
×
扫码分享
扫码分享
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1