Updates in Dermatomyositis: Newer Treatment Options and Outcome Measures From Dermatologic Perspectives.

Hee Joo Kim, Victoria P Werth
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Abstract

Dermatomyositis (DM) is a rare autoimmune connective tissue disease with characteristic skin manifestations and possible muscle involvement. Recent advances in classification system to include skin-predominant subtypes, understanding underlying pathogenic mechanisms and the relationship between clinical phenotypes and myositis-specific autoantibodies have led to development of novel therapeutic options. This corresponds with efforts to develop better outcome measures to accurately catch the patients' current disease status and treatment-induced improvements. This report will review the updates in newer treatments and outcome measures of DM, specifically from a dermatologic point of view.

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皮肌炎的最新进展:从皮肤病学角度看皮肌炎的最新治疗方案和疗效衡量标准。
皮肌炎(Dermatomyositis,DM)是一种罕见的自身免疫性结缔组织疾病,具有特征性皮肤表现,并可能累及肌肉。近年来,随着分类系统的不断进步,包括皮肤为主的亚型、对潜在致病机制的了解以及临床表型与肌炎特异性自身抗体之间关系的认识,新的治疗方案应运而生。与此同时,人们也在努力开发更好的结果测量方法,以准确捕捉患者当前的疾病状态和治疗所带来的改善。本报告将特别从皮肤病学的角度,回顾 DM 的最新治疗方法和疗效指标。
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