Blood concentrations of α-Klotho and FGF-23 exhibit no correlation with bone mineral density in elderly individuals.

IF 1.1 Q2 MEDICINE, GENERAL & INTERNAL Einstein-Sao Paulo Pub Date : 2024-09-20 eCollection Date: 2024-01-01 DOI:10.31744/einstein_journal/2024AO0412

Karina Moura Sawada, Niele Silva de Moraes, Lara Miguel Quirino Araújo, Fernanda Martins Gazoni, Marise Lazaretti-Castro, Maysa Seabra Cendoroglo, John P Bilezikian, Maria Stella Figueiredo, Fania Cristina Dos Santos

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Abstract

Objective: To investigating the relationship between α-Klotho and FGF-23 with bone biochemical markers and bone density findings in extremely aged individuals.

Methods: A total of 55 individuals with a mean age of 85.6 years were subjected to clinical, biochemical, and bone mineral density analyses and the enzyme-linked immunosorbent assay-based detection of α-Klotho and FGF-23. The mean, standard deviation, median, and interquartile ranges of the sample values were determined, and Spearman's test for association assessments was used for statistical analysis.

Results: The study participants expressed median FGF-23 and α-Klotho levels of 69.81 RU/mL (51.43 RU/mL) and 733.43 pg/mL (360.83 pg/mL), respectively. The majority of the participants possessed osteopenia (54.5%) and a vitamin D deficiency (57%). The 25-hydroxyvitamin D concentrations ranged between 7.1 and 47.5ng/mL, with a median of 18.1ng/mL.

Conclusion: No substantial associations were discovered between α-Klotho and FGF-23 levels and bone density in the study participants.

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血液中的α-Klotho和FGF-23浓度与老年人的骨质密度没有相关性。

目的研究超高龄人群中α-Klotho和FGF-23与骨生化指标和骨密度结果之间的关系：对 55 名平均年龄为 85.6 岁的老年人进行临床、生化和骨密度分析，并采用酶联免疫吸附法检测 α-Klotho 和 FGF-23。确定了样本值的平均值、标准偏差、中位数和四分位间范围，并使用斯皮尔曼关联评估检验进行了统计分析：研究参与者的 FGF-23 和 α-Klotho 水平中位数分别为 69.81 RU/mL（51.43 RU/mL）和 733.43 pg/mL（360.83 pg/mL）。大多数参与者患有骨质疏松症（54.5%）和维生素 D 缺乏症（57%）。25-羟基维生素 D 的浓度介于 7.1 至 47.5ng/mL 之间，中位数为 18.1ng/mL：结论：在研究参与者中，未发现α-Klotho和FGF-23水平与骨密度之间存在实质性关联。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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