Research Note: The Association Between Parity and Odds of Alzheimer's Disease and Dementias Status.

IF 3.6 1区社会学 Q1 DEMOGRAPHY Demography Pub Date : 2024-10-01 DOI:10.1215/00703370-11585876

Yan Zhang, Jason M Fletcher

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Abstract

While parity is a significant factor influencing parental health, its relationship with dementia remains underexplored. This research note advances the literature by conducting a well-powered analysis of associations between parity (i.e., number of children) and Alzheimer's disease and dementias (AD/D) status in large-scale population data. The data contain a large number of AD/D cases (37,228 women and 19,846 men), allowing a range (1-10) of parity associations to be estimated precisely. Using proxy (adult child's) reports of parental AD/D status, we find that both fathers and mothers with grand multiparity have decreased odds of AD/D status, and the effect sizes become larger as parity increases, with 30-40% reduction in AD/D status at parities above 7. The association is stronger for mothers than for fathers. This finding differs from much of the prior literature and likely suggests the impact of parity, as one of the important life course contexts, on people's cognitive function and risk of having AD/D. Finally, we include population projections that consider how large changes in parity distributions over time may contribute to small elevations in AD/D rates.

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研究说明：罹患阿尔茨海默病和痴呆症的几率与罹患阿尔茨海默病和痴呆症的几率之间的关系。

虽然均产是影响父母健康的一个重要因素，但其与痴呆症的关系仍未得到充分探讨。本研究报告通过对大规模人口数据中的奇偶性（即子女数量）与阿尔茨海默病和痴呆症（AD/D）状况之间的关联进行有效应对分析，推动了相关文献的研究。这些数据包含了大量的 AD/D 病例（37228 名女性和 19846 名男性），可以精确估计出一系列（1-10）的奇偶关系。通过代理（成年子女）报告父母的 AD/D 状况，我们发现，父亲和母亲的大多胎妊娠都会降低 AD/D 状况的几率，而且效应大小会随着奇数的增加而增大，奇数超过 7 时，AD/D 状况会降低 30%-40%。母亲的相关性要强于父亲。这一发现与之前的许多文献不同，很可能表明了作为重要生命历程背景之一的奇偶性对人们认知功能和患有 AD/D 风险的影响。最后，我们纳入了人口预测，考虑了随着时间的推移奇偶分布的巨大变化如何可能导致注意力缺失症/痴呆症发病率的小幅上升。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Demography DEMOGRAPHY-

CiteScore

5.90

自引率

2.90%

发文量

期刊介绍： Since its founding in 1964, the journal Demography has mirrored the vitality, diversity, high intellectual standard and wide impact of the field on which it reports. Demography presents the highest quality original research of scholars in a broad range of disciplines, including anthropology, biology, economics, geography, history, psychology, public health, sociology, and statistics. The journal encompasses a wide variety of methodological approaches to population research. Its geographic focus is global, with articles addressing demographic matters from around the planet. Its temporal scope is broad, as represented by research that explores demographic phenomena spanning the ages from the past to the present, and reaching toward the future. Authors whose work is published in Demography benefit from the wide audience of population scientists their research will reach. Also in 2011 Demography remains the most cited journal among population studies and demographic periodicals. Published bimonthly, Demography is the flagship journal of the Population Association of America, reaching the membership of one of the largest professional demographic associations in the world.