A toxicogenomics-based identification of potential mechanisms and signaling pathways involved in PFCs-induced cancer in human.

IF 2.2 4区 医学 Q3 TOXICOLOGY Toxicology Research Pub Date : 2024-09-24 eCollection Date: 2024-10-01 DOI:10.1093/toxres/tfae151
Zahra Dehghani, Sara Ranjbar, Farbod Shahabinezhad, Pooria Sabouri, Afshin Mohammadi Bardbori
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Abstract

Introduction: The number of new diagnosed cancer cases and cancer deaths are increasing worldwide. Perfluorinated compounds (PFCs) are synthetic chemicals, which are possible inducers of cancer in human and laboratory animals. Studies showed that PFCs induce breast, prostate, kidney, liver and pancreas cancer by inducing genes being involved in carcinogenic pathways.

Methodology: This study reviews the association between PFCs induced up-regulation/down-regulation of genes and signaling pathways that are important in promoting different types of cancer. To obtain chemical-gene interactions, an advanced search was performed in the Comparative Toxicogenomics Database platform.

Results: Five most prevalent cancers were studied and the maps of their signaling pathways were drawn, and colored borders indicate significantly differentially expressed genes if there had been reports of alterations in expression in the presence of PFCs.

Conclusion: In general, PFCs are capable of inducing cancer in human via altering PPARα and PI3K pathways, evading apoptosis, inducing sustained angiogenesis, alterations in proliferation and blocking differentiation. However, more epidemiological data and mechanistic studies are needed to better understand the carcinogenic effects of PFCs in human.

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基于毒物基因组学鉴定全氟化合物诱发人类癌症的潜在机制和信号通路。
导 言全球新确诊癌症病例和癌症死亡人数不断增加。全氟化合物(PFCs)是一种合成化学品,可能诱发人类和实验动物癌症。研究表明,全氟化合物通过诱导参与致癌途径的基因,诱发乳腺癌、前列腺癌、肾癌、肝癌和胰腺癌:本研究回顾了全氟化合物诱导基因上调/下调与信号通路之间的关联,这些基因和信号通路对促进不同类型癌症的发生非常重要。为了获得化学物质与基因之间的相互作用,我们在比较毒物基因组学数据库平台上进行了高级搜索:结果:对五种最常见的癌症进行了研究,并绘制了其信号通路图,如果有报道称在全氟化学品存在的情况下基因的表达发生了改变,则用彩色边框表示表达显著不同的基因:总的来说,全氟化合物能够通过改变 PPARα 和 PI3K 通路、逃避凋亡、诱导持续血管生成、改变增殖和阻止分化来诱发人类癌症。然而,要更好地了解全氟化合物对人体的致癌作用,还需要更多的流行病学数据和机理研究。
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来源期刊
Toxicology Research
Toxicology Research TOXICOLOGY-
CiteScore
3.60
自引率
0.00%
发文量
82
期刊介绍: A multi-disciplinary journal covering the best research in both fundamental and applied aspects of toxicology
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