The inositol phosphate signalling network in physiology and disease

IF 11.6 1区 生物学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY Trends in Biochemical Sciences Pub Date : 2024-11-01 DOI:10.1016/j.tibs.2024.08.005
Seyun Kim , Rashna Bhandari , Charles A. Brearley , Adolfo Saiardi
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Abstract

Combinatorial substitution of phosphate groups on the inositol ring gives rise to a plethora of inositol phosphates (InsPs) and inositol pyrophosphates (PP-InsPs). These small molecules constitute an elaborate metabolic and signalling network that influences nearly every cellular function. This review delves into the knowledge accumulated over the past decades regarding the biochemical principles and significance of InsP metabolism. We focus on the biological actions of InsPs in mammals, with an emphasis on recent findings regarding specific target proteins. We further discuss the roles of InsP metabolism in contributing to physiological homeostasis and pathological conditions. A deeper understanding of InsPs and their metabolic pathways holds the potential to address unresolved questions and propel advances towards therapeutic applications.
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生理和疾病中的磷酸肌醇信号网络。
肌醇环上磷酸基团的组合取代产生了大量肌醇磷酸盐(InsPs)和肌醇焦磷酸盐(PP-InsPs)。这些小分子构成了一个复杂的代谢和信号网络,影响着几乎所有的细胞功能。本综述深入探讨了过去几十年中积累的有关 InsP 代谢的生化原理和意义的知识。我们重点探讨了 InsPs 在哺乳动物体内的生物作用,并着重介绍了有关特定靶蛋白的最新发现。我们进一步讨论了 InsP 代谢在生理平衡和病理状态中的作用。加深对 InsPs 及其代谢途径的了解有可能解决悬而未决的问题,并推动治疗应用的进展。
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来源期刊
Trends in Biochemical Sciences
Trends in Biochemical Sciences 生物-生化与分子生物学
CiteScore
22.90
自引率
0.70%
发文量
148
审稿时长
6-12 weeks
期刊介绍: For over 40 years, Trends in Biochemical Sciences (TIBS) has been a leading publication keeping readers informed about recent advances in all areas of biochemistry and molecular biology. Through monthly, peer-reviewed issues, TIBS covers a wide range of topics, from traditional subjects like protein structure and function to emerging areas in signaling and metabolism. Articles are curated by the Editor and authored by top researchers in their fields, with a focus on moving beyond simple literature summaries to providing novel insights and perspectives. Each issue primarily features concise and timely Reviews and Opinions, supplemented by shorter articles including Spotlights, Forums, and Technology of the Month, as well as impactful pieces like Science & Society and Scientific Life articles.
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