Changes in Bladder Volume During Radiotherapy for Prostate Cancer.

IF 1.6 4区 医学 Q4 ONCOLOGY Anticancer research Pub Date : 2024-10-01 DOI:10.21873/anticanres.17275
Dirk Rades, Florian Cremers, Christian Ziemann, Laura Splettstösser, Carlos A Narvaez-Wolf, Ahmed Al-Salool, Michael VON Staden, Jan-Dirk Küter, Stefan Janssen, Carmen Timke
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Abstract

Background/aim: Patients irradiated for prostate cancer may experience urinary toxicity, particularly if the bladder volume is small. A mobile application (app) that reminds the patients to drink water prior to each radiation fraction may help avoid small volumes. This study investigating bladder volumes during a radiotherapy course is a prerequisite for a prospective trial testing such a reminder app.

Patients and methods: Frequency of bladder volumes <200 ml and seven potential risk factors were retrospectively evaluated in 72 patients receiving external beam radiotherapy for non-metastatic prostate cancer.

Results: The mean and median values of the numbers of radiation fractions with bladder volumes <200 ml were 17.8 (standard deviation=12.0) and 16.5 (interquartile range Q1-Q3=7.5-29.5) fractions, respectively. Higher numbers of fractions with volumes <200 ml were significantly associated with pre-radiotherapy bladder volumes <200 ml (p<0.001) and high-risk prostate cancer (p=0.014).

Conclusion: The proportion of bladder volumes <200 ml during the radiotherapy course was high and needs to be decreased. Pre-radiotherapy bladder volume and risk level of prostate cancer were significant risk factors for higher numbers of fractions with volumes <200 ml. These results are important for designing a prospective trial.

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前列腺癌放疗期间膀胱容量的变化
背景/目的:接受前列腺癌照射的患者可能会出现泌尿系统毒性,尤其是在膀胱容量较小的情况下。提醒患者在每次放疗前喝水的移动应用程序(App)可能有助于避免尿量过少。这项调查放疗过程中膀胱容量的研究是测试此类提醒应用的前瞻性试验的前提条件:膀胱容量的频率 结果:有膀胱容量的放疗次数的平均值和中位值 结论:有膀胱容量的放疗次数比例较高:膀胱容量的比例
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来源期刊
Anticancer research
Anticancer research 医学-肿瘤学
CiteScore
3.70
自引率
10.00%
发文量
566
审稿时长
2 months
期刊介绍: ANTICANCER RESEARCH is an independent international peer-reviewed journal devoted to the rapid publication of high quality original articles and reviews on all aspects of experimental and clinical oncology. Prompt evaluation of all submitted articles in confidence and rapid publication within 1-2 months of acceptance are guaranteed. ANTICANCER RESEARCH was established in 1981 and is published monthly (bimonthly until the end of 2008). Each annual volume contains twelve issues and index. Each issue may be divided into three parts (A: Reviews, B: Experimental studies, and C: Clinical and Epidemiological studies). Special issues, presenting the proceedings of meetings or groups of papers on topics of significant progress, will also be included in each volume. There is no limitation to the number of pages per issue.
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