Nondysplastic Colon Crypts Intercalated in Tubular Adenomas Support Field Cancerization.

IF 1.6 4区 医学 Q4 ONCOLOGY Anticancer research Pub Date : 2024-10-01 DOI:10.21873/anticanres.17266
Carlos A Rubio, Michael Vieth, Corinna Lang-Schwarz
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Abstract

Background/aim: Tubular adenomas of the colon (TA) are neoplastic polyps composed of dysplastic tube-like crypts. Nondysplastic crypts, mostly in asymmetric branching have been previously reported, both beneath and bordering TA. In the present article, intercalated nondysplastic crypts (INDC) amidst dysplastic crypts in TA are showcased.

Patients and methods: The occurrence of INDC was recorded in 139 TA.

Results: Out of the 139 TA, 31% exhibited INDC; of these, 58% were in asymmetric branching (INDCAB), 35% were single intercalated crypts without branching (INDSNB), and 7% were in symmetric branching (INDCSB). Luminal dysplasia occurred in 53% out of the 43 TA: in 37% TA with INDCAB, in 16% TA with INDSNB, but in none of the TA with INDCSB. Thus, INDCAB predominated.

Conclusion: The finding of INDC in TA domain contrasts with the infrequency of INDCSB and with the absence of INDCAB in the normal colorectal mucosa. Hence, INDC emerge as integral components in TA. Since only 1 or 2 sections were available per TA, the total number of INDC in the entire TA is likely higher. INDC in TA may be remnants of acquired nondysplastic mucosal cores of abnormal cryptogenesis that were subsequently replaced by top-down growing dysplastic epithelium. The present and previous findings support the concept of field cancerization in the human colorectum.

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管状腺瘤中夹杂的非增生性结肠隐窝支持现场癌化。
背景/目的:结肠管状腺瘤(TA)是由发育不良的管状隐窝组成的肿瘤性息肉。非增生性隐窝以前也有报道,大多呈不对称分支,既位于结肠管状腺瘤下方,也与结肠管状腺瘤相邻。本文展示了TA中发育不良的隐窝中夹杂的非增生性隐窝(INDC):患者和方法:记录了139例TA中INDC的发生情况:结果:在139例TA中,31%出现INDC;其中58%为非对称分支(INDCAB),35%为无分支的单个闰隐窝(INDSNB),7%为对称分支(INDCSB)。在43个TA中,53%出现管腔发育不良:37%的TA为INDCAB,16%的TA为INDSNB,但没有一个TA为INDCSB。因此,INDCAB占主导地位:结论:在 TA 中发现 INDC 与 INDCSB 不常见以及正常结直肠粘膜中不存在 INDCAB 形成鲜明对比。因此,INDC 是 TA 不可或缺的组成部分。由于每个 TA 只有 1 或 2 个切片,因此整个 TA 中 INDC 的总数可能更高。TA 中的 INDC 可能是后天非增生异常隐窝粘膜核心的残留物,随后被自上而下生长的增生异常上皮所取代。目前和以前的研究结果都支持人类结直肠中的野癌化概念。
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来源期刊
Anticancer research
Anticancer research 医学-肿瘤学
CiteScore
3.70
自引率
10.00%
发文量
566
审稿时长
2 months
期刊介绍: ANTICANCER RESEARCH is an independent international peer-reviewed journal devoted to the rapid publication of high quality original articles and reviews on all aspects of experimental and clinical oncology. Prompt evaluation of all submitted articles in confidence and rapid publication within 1-2 months of acceptance are guaranteed. ANTICANCER RESEARCH was established in 1981 and is published monthly (bimonthly until the end of 2008). Each annual volume contains twelve issues and index. Each issue may be divided into three parts (A: Reviews, B: Experimental studies, and C: Clinical and Epidemiological studies). Special issues, presenting the proceedings of meetings or groups of papers on topics of significant progress, will also be included in each volume. There is no limitation to the number of pages per issue.
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