The Dominant Component and Clinicopathological Characteristics of Combined Hepatocellular-cholangiocarcinoma After Radical Resection.

IF 1.6 4区 医学 Q4 ONCOLOGY Anticancer research Pub Date : 2024-10-01 DOI:10.21873/anticanres.17284
Keiso Matsubara, Tsuyoshi Kobayashi, Takeshi Tadokoro, Yosuke Namba, Sotaro Fukuhara, K O Oshita, Naruhiko Honmyo, Shintaro Kuroda, Koji Arihiro, Hideki Ohdan
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Abstract

Background/aim: Combined hepatocellular cholangiocarcinoma (cHCC-CCA) is a rare subtype of primary liver carcinoma, characterized by the unequivocal presence of both hepatocellular carcinoma (HCC) and intrahepatic cholangiocarcinoma (iCCA). However, its clinicopathological characteristics have not yet been thoroughly elucidated. In particular, cholangiolocellular carcinoma (CLC) was classified as a subtype of cHCC-CCA according to the 2010 World Health Organization (WHO) classification. However, according to the 2019 WHO classification, tumors displaying histological features consistent with CLC but lacking evidence of hepatocellular differentiation should be regarded as a distinct subtype of iCCA. Nevertheless, there may be notable differences in prognosis between CLC and iCCA, indicating the necessity for refining the classification when devising clinical treatment strategies. This study aimed to determine the clinicopathological features and prognostic factors of cHCC-CCAs following radical resection.

Patients and methods: Between January 2010 and September 2020, based on the 2010 WHO classification, we retrospectively studied the clinicopathological features and prognoses of patients with cHCC-CCAs in relation to the pathological dominant classification. The patients were classified according to the pathological dominant components of cHCC-CCA as HCC-dominant (HCC-D), iCCA-dominant (iCCA-D), or CLC-dominant (CLC-D).

Results: Data of 55 patients who underwent primary radical hepatectomy for cHCC-CCA were analyzed. The prevalences of each dominant classification were HCC-D, 21 (38.2%); iCCA-D, 11 (20.0%); and CLC-D, 23 (41.8%). Multivariate analysis showed that dominant classification was an independent risk factor for recurrence and cancer-specific survival (CSS).

Conclusion: The dominant classification of cHCC-CCA has the potential to predict recurrence and CSS.

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根治性切除术后合并肝细胞胆管癌的主要成分和临床病理特征
背景/目的:合并肝细胞胆管癌(cHCC-CCA)是原发性肝癌的一种罕见亚型,其特点是同时明确存在肝细胞癌(HCC)和肝内胆管癌(iCCA)。然而,其临床病理特征尚未得到彻底阐明。特别是,根据 2010 年世界卫生组织(WHO)的分类,胆管细胞癌(CLC)被归类为 cHCC-CCA 的一个亚型。然而,根据 2019 年世界卫生组织的分类,显示与 CLC 一致的组织学特征但缺乏肝细胞分化证据的肿瘤应被视为 iCCA 的一个独特亚型。然而,CLC 和 iCCA 的预后可能存在显著差异,这表明在制定临床治疗策略时有必要完善分类。本研究旨在确定cHCC-CCAs根治性切除术后的临床病理特征和预后因素:2010年1月至2020年9月期间,根据2010年WHO分类,我们回顾性研究了cHCC-CCAs患者的临床病理特征和预后与病理优势分类的关系。根据 cHCC-CCA 的病理显性成分将患者分为 HCC-显性(HCC-D)、iCCA-显性(iCCA-D)或 CLC-显性(CLC-D):结果:分析了55例接受原发性根治性肝切除术治疗的cHCC-CCA患者的数据。各优势分类的发生率分别为:HCC-D,21 例(38.2%);iCCA-D,11 例(20.0%);CLC-D,23 例(41.8%)。多变量分析显示,显性分类是复发和癌症特异性生存率(CSS)的独立风险因素:结论:cHCC-CCA的优势分类有可能预测复发和CSS。
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来源期刊
Anticancer research
Anticancer research 医学-肿瘤学
CiteScore
3.70
自引率
10.00%
发文量
566
审稿时长
2 months
期刊介绍: ANTICANCER RESEARCH is an independent international peer-reviewed journal devoted to the rapid publication of high quality original articles and reviews on all aspects of experimental and clinical oncology. Prompt evaluation of all submitted articles in confidence and rapid publication within 1-2 months of acceptance are guaranteed. ANTICANCER RESEARCH was established in 1981 and is published monthly (bimonthly until the end of 2008). Each annual volume contains twelve issues and index. Each issue may be divided into three parts (A: Reviews, B: Experimental studies, and C: Clinical and Epidemiological studies). Special issues, presenting the proceedings of meetings or groups of papers on topics of significant progress, will also be included in each volume. There is no limitation to the number of pages per issue.
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