Assessing sociability using the Three-Chamber Social Interaction Test and the Reciprocal Interaction Test in a genetic mouse model of ASD.

IF 4.7 2区 心理学 Q1 BEHAVIORAL SCIENCES Behavioral and Brain Functions Pub Date : 2024-09-28 DOI:10.1186/s12993-024-00251-0
Jakub Szabó, Emese Renczés, Veronika Borbélyová, Daniela Ostatníková, Peter Celec
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Abstract

Autism Spectrum Disorder (ASD) is a group of neurodevelopmental disorders with heterogeneous symptomatology. Arguably, the most pervasive shortfall of ASD are the deficits in sociability and the animal models of the disorder are expected to exhibit such impairments. The most widely utilized behavioral task for assessing sociability in rodents is the Three-Chamber Social Interaction Test (SIT). However, SIT has been yielding inconsistent results in social interaction behavior across different rodent models of ASD, which could be pointing to the suboptimal methodology of the task. Here, we compared social behavior assessed in SIT and in another prominent sociability behavioral assay, Reciprocal Interaction Test (RCI), in a SH3 and multiple ankyrin repeated domains 3 (SHANK3) mouse model of ASD. Head-to-head comparison showed no association (p = 0.15, 0.25, 0.43) and a fixed bias (p = 0.01, < 0.001, < 0.001) in sociability assessment between the behavioral assays in both wild-type (WT) controls and Shank3B(-/-) mice. Adult Shank3B(-/-) mice of both sexes displayed normative sociability in SIT when compared to the WT controls (p = 0.74) but exhibited less than half of social interaction (p < 0.001) and almost three times more social disinterest (p < 0.001) when compared to WT mice in RCI. At least in the Shank3B(-/-) mouse model of ASD, we presume RCI could be a preferable way of assessing social interaction compared to SIT. Considering the variability of animal models of ASD and the wide palette of tools available for the assessment of their behavior, a consensus approach would be needed for observational and interventional analyses.

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利用三腔室社会互动测试和互惠互动测试评估遗传小鼠 ASD 模型的社交能力。
自闭症谱系障碍(ASD)是一组症状各异的神经发育障碍。可以说,自闭症最普遍的缺陷是交际能力不足,而自闭症的动物模型也会表现出这种障碍。用于评估啮齿类动物社交能力的最广泛使用的行为任务是三腔社交互动测试(SIT)。然而,在不同的啮齿动物 ASD 模型中,三腔社交互动测试得出的社交互动行为结果并不一致,这可能与该任务的方法不当有关。在这里,我们比较了在SH3和多ankin重复结构域3(SHANK3)ASD小鼠模型中进行的SIT社交行为评估和另一种著名的社交行为评估--互惠互动测试(RCI)。头对头比较显示,小鼠之间没有关联(p = 0.15、0.25、0.43),但存在固定偏差(p = 0.01,(-/-)小鼠)。与 WT 对照组相比,成年 Shank3B(-/-)雌雄小鼠在 SIT 中表现出正常的社交能力(p = 0.74),但表现出的社交互动却不到 WT 对照组的一半(p (-/-))。考虑到 ASD 动物模型的多变性和评估其行为的多种工具,观察和干预分析需要一种共识方法。
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来源期刊
Behavioral and Brain Functions
Behavioral and Brain Functions 医学-行为科学
CiteScore
5.90
自引率
0.00%
发文量
11
审稿时长
6-12 weeks
期刊介绍: A well-established journal in the field of behavioral and cognitive neuroscience, Behavioral and Brain Functions welcomes manuscripts which provide insight into the neurobiological mechanisms underlying behavior and brain function, or dysfunction. The journal gives priority to manuscripts that combine both neurobiology and behavior in a non-clinical manner.
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