Assessments of coagulation profile among good glycemic control and poor glycemic control type 2 diabetic patient attending at Wolkite University specialized hospital, Central Ethiopia: a comparative study.

IF 2.8 3区 医学 Q3 ENDOCRINOLOGY & METABOLISM BMC Endocrine Disorders Pub Date : 2024-09-30 DOI:10.1186/s12902-024-01730-1
Bisrat Fikadu Habtu, Seid Abrar, Dereje Abebe, Zuber Hajikelil
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Abstract

Introduction: Diabetes Mellitus (DM) is a worldwide health issue that is defined by elevated blood glucose levels and impaired metabolism of fat, carbohydrates, and proteins. Atherosthrombotic events are very likely to occur in patients with diabetes mellitus. This results in the development of both microvascular and macrovascular complications.

Objective: To compare the coagulation profile parameters between patients with good glycemic control and poor glycemic control and to evaluate the association of coagulation profile and glycemic control in type 2 DM patients.

Materials and methods: This study was conducted in Wolkite university specialized hospital on 90 type 2 Diabetics patients among which 45 were with good glycemic control and 45 were with poor glycemic control. Seven ml blood samples were collected from each study participant and analyzed to assess coagulation profile including Platelet Count, activated Partial Thromboplastin Time (aPTT), and Prothrombin Time (PT). Using SPSS 21.0, an independent sample t-test was used for statistical analysis.

Results: According to the current study, when comparing Type 2 Diabetes with poor glycemic control to those with good glycemic control, there was an increase in PT and aPTT concentration (statistically significant, p < 0.05). The platelet counts of the two groups did not differ significantly.

Conclusion: People with Type 2 diabetes have altered coagulation profiles, which have demonstrated that hyperglycemia causes abnormalities in coagulation. Patients with Type 2 diabetes who have poor glycemic control are particularly vulnerable to atherothrombotic and hemorrhagic events. In order to prevent the onset of microvascular and macrovascular illness as soon as possible, physicians may find it helpful to evaluate the coagulation profile of diabetic patients.

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在埃塞俄比亚中部沃尔基特大学专科医院就诊的血糖控制良好和血糖控制不佳的 2 型糖尿病患者的凝血状况评估:一项比较研究。
简介糖尿病(DM)是一个世界性的健康问题,表现为血糖水平升高以及脂肪、碳水化合物和蛋白质的新陈代谢受损。糖尿病患者很容易发生动脉粥样硬化血栓事件。目的:比较糖尿病患者的凝血功能指标:比较血糖控制良好和血糖控制不佳患者的凝血谱参数,并评估 2 型糖尿病患者凝血谱与血糖控制的关联:本研究在沃尔凯特大学专科医院对 90 名 2 型糖尿病患者进行了研究,其中 45 名患者血糖控制良好,45 名患者血糖控制不佳。研究人员采集了每位患者的 7 毫升血液样本,并对其进行分析,以评估凝血情况,包括血小板计数、活化部分凝血活酶时间(aPTT)和凝血酶原时间(PT)。统计分析采用 SPSS 21.0 进行独立样本 t 检验:本次研究显示,血糖控制不佳的 2 型糖尿病患者与血糖控制良好的 2 型糖尿病患者相比,PT 和 aPTT 浓度增加(具有统计学意义,P 结论:血糖控制不佳的 2 型糖尿病患者与血糖控制良好的 2 型糖尿病患者相比,PT 和 aPTT 浓度增加(具有统计学意义,P 结论):2 型糖尿病患者的凝血功能会发生改变,这表明高血糖会导致凝血功能异常。血糖控制不佳的 2 型糖尿病患者特别容易发生动脉粥样血栓和出血事件。为了尽快预防微血管和大血管疾病的发生,医生可能会发现对糖尿病患者的凝血功能进行评估很有帮助。
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来源期刊
BMC Endocrine Disorders
BMC Endocrine Disorders ENDOCRINOLOGY & METABOLISM-
CiteScore
4.40
自引率
0.00%
发文量
280
审稿时长
>12 weeks
期刊介绍: BMC Endocrine Disorders is an open access, peer-reviewed journal that considers articles on all aspects of the prevention, diagnosis and management of endocrine disorders, as well as related molecular genetics, pathophysiology, and epidemiology.
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