Different taste map for amiloride sensitivity, response frequency, and threshold to NaCl in the rostral nucleus of the solitary tract in rats.

IF 2.8 4区 心理学 Q1 BEHAVIORAL SCIENCES Chemical Senses Pub Date : 2024-01-01 DOI:10.1093/chemse/bjae036
Tatsuko Yokota, Katsunari Hiraba
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Abstract

Studies on taste bud cells and brain stem relay nuclei suggest that alternative pathways convey information regarding different taste qualities. Building on the hypothesis that amiloride (epithelial Na channel antagonist)-sensitive neurons respond to palatable salt (low-concentration) and amiloride-insensitive neurons respond to aversive salt (high-concentration), we investigated the histological distribution of taste-sensitive neurons in the rostral nucleus of the solitary tract in rats and their NaCl and amiloride sensitivities. We recorded neuronal activity in extracellular single units using multi-barrel glass micropipettes and reconstructed their locations on the rostrocaudal and mediolateral axes. Seventy-three taste-sensitive neurons were categorized into the best-taste category. The amiloride sensitivities of the 31 neurons were examined for 0.1, 0.2, 0.4, and 0.8 M NaCl. The neuronal distribution of amiloride-sensitive neurons was located in the lateral region, while amiloride-insensitive neurons were located in the medial region. The amiloride-sensitive neurons responded to low salt concentrations, signaling the NaCl levels required by body fluids. Amiloride-insensitive neurons were silent at low salt concentrations but may function as warning signals for high salt concentrations. Low-threshold and/or high-response neurons were located in the rostrolateral region. In contrast, high-threshold and/or low-response neurons were located in the caudal-medial region.

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大鼠孤束喙核中氨苯蝶啶对氯化钠的敏感性、反应频率和阈值的不同味觉图谱
对味蕾细胞和脑干中继核的研究表明,不同的味觉质量有不同的信息传递途径。基于阿米洛利(上皮 Na 通道拮抗剂)敏感神经元对适口盐(低浓度)和阿米洛利不敏感神经元对厌恶盐(高浓度)反应的假设,我们研究了大鼠孤束喙核中味觉敏感神经元的组织学分布及其对 NaCl 和阿米洛利的敏感性。我们使用多管玻璃微量滴管记录了细胞外单个单元的神经元活动,并重建了它们在喙尾轴和内外侧轴上的位置。73个味觉敏感神经元被归入最佳味觉类别。对这 31 个神经元的阿米洛利敏感性进行了检测,检测浓度分别为 0.1、0.2、0.4 和 0.8 M NaCl。对阿米洛利敏感的神经元分布在外侧区域,而对阿米洛利不敏感的神经元分布在内侧区域。氨苯蝶啶敏感神经元对低盐浓度有反应,表明体液所需的氯化钠水平。氨苯蝶啶不敏感神经元在低盐浓度时保持沉默,但可能对高盐浓度起警示作用。低阈值和/或高反应神经元位于喙外侧区域。相反,高阈值和/或低反应神经元位于尾内侧区域。
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来源期刊
Chemical Senses
Chemical Senses 医学-行为科学
CiteScore
8.60
自引率
2.90%
发文量
25
审稿时长
1 months
期刊介绍: Chemical Senses publishes original research and review papers on all aspects of chemoreception in both humans and animals. An important part of the journal''s coverage is devoted to techniques and the development and application of new methods for investigating chemoreception and chemosensory structures.
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