Effect of age, sex, and chronic kidney disease on urinary creatinine excretion in Japanese patients.

IF 2.2 4区医学 Q2 UROLOGY & NEPHROLOGY Clinical and Experimental Nephrology Pub Date : 2024-09-27 DOI:10.1007/s10157-024-02569-5

Shigehiro Yasui, Taro Horino, Keita Mitani, Yoshio Terada, Yoshiyasu Okuhara, Yutaka Hatakeyama

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Abstract

Background: Urinary creatinine levels are used to estimate the excretion rates of certain analytes from the respective analyte-to-creatinine ratios. We clarified the influence of age and sex on estimated daily urinary creatinine excretion (eUCrE) based on the urinary creatinine level and daily urine volume.

Methods: All inpatients aged ≥ 18 years who attended the Kochi Medical School Hospital with serum and urinary creatinine measurement results were enrolled. Serum and urinary creatinine concentrations were extracted from the database and fluctuations with sex and age were investigated. The eUCrE was calculated for patients with early morning spot urine protein excretion (UPE), and daily urine volume was measured on the same day.

Results: Overall, 643 participants (322 men, 321 women) were enrolled. The eUCrE levels of men and women aged 18 - 64 and 18 - 44 years, respectively, significantly exceeded 1 g/day. Those of women aged 65-74 and ≥ 75 years were significantly lower than 1 g/day. Each age group was further categorised into Groups A (patients with eGFR ≥ 30 mL/min/1.73 m² and UPE < 0.5 g/gCr), B (eGFR ≥ 30 mL/min/1.73 m² and UPE ≥ 0.5 g/gCr), and C (eGFR < 30 mL/min/1.73 m² and UPE ≥ 0.5 g/gCr). The eUCrE levels were the highest in Group A, followed by Groups B and C.

Conclusion: This study revealed age-, sex-, and renal function-related biases in adjusted values using urinary biomarkers, including proteinuria and creatinine ratio.

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日本患者的年龄、性别和慢性肾病对尿肌酐排泄的影响

背景：尿肌酐水平用于根据分析物与肌酐的比率估算某些分析物的排泄率。我们根据尿肌酐水平和每日尿量，阐明了年龄和性别对估计每日尿肌酐排泄量（eUCrE）的影响：所有在高知医学院附属医院就诊且有血清和尿肌酐测量结果的年龄≥18 岁的住院患者均被纳入研究对象。从数据库中提取血清和尿肌酐浓度，并调查其随性别和年龄的波动情况。对清晨定点尿蛋白排泄量（UPE）的患者计算 eUCrE，并在同一天测量每日尿量：结果：共有 643 人（男性 322 人，女性 321 人）参加了研究。年龄分别为 18 - 64 岁和 18 - 44 岁的男性和女性的 eUCrE 水平明显超过每天 1 克。而 65-74 岁和≥ 75 岁女性的 eUCrE 水平则明显低于 1 克/天。每个年龄组又分为 A 组（eGFR ≥ 30 mL/min/1.73 m2 和 UPE 2 和 UPE ≥ 0.5 g/gCr 的患者）和 C 组（eGFR 2 和 UPE ≥ 0.5 g/gCr 的患者）。A 组的 eUCrE 水平最高，其次是 B 组和 C 组：本研究揭示了使用尿液生物标志物（包括蛋白尿和肌酐比值）调整值时与年龄、性别和肾功能相关的偏差。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Clinical and Experimental Nephrology UROLOGY & NEPHROLOGY-

CiteScore

4.10

自引率

4.30%

发文量

135

审稿时长

4-8 weeks

期刊介绍： Clinical and Experimental Nephrology is a peer-reviewed monthly journal, officially published by the Japanese Society of Nephrology (JSN) to provide an international forum for the discussion of research and issues relating to the study of nephrology. Out of respect for the founders of the JSN, the title of this journal uses the term “nephrology,” a word created and brought into use with the establishment of the JSN (Japanese Journal of Nephrology, Vol. 2, No. 1, 1960). The journal publishes articles on all aspects of nephrology, including basic, experimental, and clinical research, so as to share the latest research findings and ideas not only with members of the JSN, but with all researchers who wish to contribute to a better understanding of recent advances in nephrology. The journal is unique in that it introduces to an international readership original reports from Japan and also the clinical standards discussed and agreed by JSN.