Role of Interleukin-17 in Predicting Activity of Rheumatoid Arthritis and Systemic Lupus Erythematosus.

IF 1.9 Q2 ORTHOPEDICS Clinical Medicine Insights. Arthritis and Musculoskeletal Disorders Pub Date : 2024-09-17 eCollection Date: 2024-01-01 DOI:10.1177/11795441241276880
Sara F Samaan, Sara I Taha, Fatma A Mahmoud, Yara Elsaadawy, Salma A Khalil, Dalia M Gamal
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Abstract

Background: Although high serum levels of interleukin (IL)-17 and its producing cells have been found in rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE) in earlier research, it is still unclear how these findings relate to disease activity.

Objectives: This study examines the link between serum levels of IL-17 and the activity of both RA and SLE.

Design: This pilot case-control study included 100 patients with RA, 100 with SLE, and 100 healthy controls.

Methods: The Disease Activity Score-28 (DAS28) scores assessed the activity of RA, whereas the Systemic Lupus Erythematosus Disease Activity Index 2000 (SLEDAI-2K) scores assessed SLE activity. All participants' data were compared and correlated.

Results: Serum levels of IL-17 were significantly higher in RA and SLE patients compared with the controls (P < .001) and showed significantly positive correlations (P < .001) with rheumatoid factor titer, anti-cyclic citrullinated peptide (anti-CCP) and DAS28 score among the RA patients. Although among SLE patients, they were significantly positively correlated (P < .001) with anti-double-stranded DNA (anti-ds DNA) levels and the SLEDAI-2K scores, the best cut-off value of IL-17 for predicting moderate and high disease activity was > 175 pg/mL among RA patients and > 95 pg/mL among SLE patients.

Conclusions: There is a significant correlation between RA and SLE activity and serum levels of IL-17. This discovery emphasizes IL-17 as a potential therapeutic target.

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白细胞介素-17 在预测类风湿关节炎和系统性红斑狼疮活动中的作用
背景:尽管早期研究发现类风湿性关节炎(RA)和系统性红斑狼疮(SLE)患者血清中白细胞介素(IL)-17及其产生细胞的水平较高,但目前仍不清楚这些发现与疾病活动性之间的关系:本研究探讨了血清中 IL-17 水平与 RA 和系统性红斑狼疮活动性之间的联系:这项试验性病例对照研究包括100名RA患者、100名系统性红斑狼疮患者和100名健康对照者:疾病活动度评分-28(DAS28)评估了RA的活动度,而系统性红斑狼疮疾病活动度指数2000(SLEDAI-2K)评估了系统性红斑狼疮的活动度。对所有参与者的数据进行了比较和关联分析:结果:与对照组相比,RA 和系统性红斑狼疮患者血清中的 IL-17 水平明显更高(RA 患者为 175 pg/mL,系统性红斑狼疮患者大于 95 pg/mL):结论:RA 和系统性红斑狼疮的活动与血清中的 IL-17 水平之间存在明显的相关性。结论:RA 和系统性红斑狼疮的活动性与血清中 IL-17 的水平有明显的相关性,这一发现强调了 IL-17 是一个潜在的治疗靶点。
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来源期刊
CiteScore
4.40
自引率
0.00%
发文量
14
审稿时长
8 weeks
期刊最新文献
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