Investigating the Link between Psychological Well-Being and Early-Stage Age-Related Macular Degeneration: A Mendelian Randomization Analysis.

IF 1.7 4区 医学 Q3 OPHTHALMOLOGY Current Eye Research Pub Date : 2024-09-27 DOI:10.1080/02713683.2024.2408757
Jie Deng, YuHui Qin
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Abstract

Purpose: While some studies have started to focus on the link between psychological well-being and age-related macular degeneration (AMD), the relationship remains uncertain. Our research aims to provide new insights into this association, laying a foundation for future interventions and addressing existing knowledge gaps.

Methods: We utilized the "TwoSampleMR" package in R for a bidirectional Mendelian randomization analysis of psychological well-being (subjective well-being, depression, neuroticism, and Sensitivity to Environmental Stress and Adversity) and early-stage AMD. Causal effects were estimated using the inverse-variance weighted method, and additional methods included weighted median and MR-Egger regression. Sensitivity analyses included Cochran's Q test, MR-Egger intercept analysis, MR-PRESSO, and leave-one-out analysis.

Results: The study found that the population with genetic predisposition to neuroticism had a 39.7% lower risk of early-stage AMD (OR = 0.603, 95% CI = 0.385-0.945, p = 0.027). Conversely, the population with genetic predisposition to subjective well-being had a 3.2% increased risk of early-stage AMD (OR = 1.032, 95% CI = 1.003-1.063, p = 0.029). No significant causal relationships were found from depression or Sensitivity to Environmental Stress and Adversity to early-stage AMD, nor from early-stage AMD to psychological well-being.

Conclusion: This study provides preliminary evidence that the relationship between psychological well-being and early-stage AMD may be complex and multifaceted. It suggests that moderate neuroticism levels might reduce early-stage AMD risk through health behaviors, pathophysiological mechanisms, and other factors, while high subjective well-being levels might increase this risk similarly. However, these findings are insufficient for preventive strategies due to a lack of substantial evidence and still require extensive experimental research for further validation.

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研究心理健康与早期老年性黄斑变性之间的联系:孟德尔随机分析。
目的:虽然一些研究已经开始关注心理健康与老年性黄斑变性(AMD)之间的联系,但这种关系仍然不确定。我们的研究旨在为这一关系提供新的见解,为未来的干预措施奠定基础,并解决现有的知识空白:我们利用 R 软件包 "TwoSampleMR "对心理健康(主观幸福感、抑郁、神经质以及对环境压力和逆境的敏感性)和早期 AMD 进行了双向孟德尔随机分析。因果效应采用逆方差加权法进行估计,其他方法包括加权中位数和MR-Egger回归。敏感性分析包括 Cochran's Q 检验、MR-Egger 截距分析、MR-PRESSO 和遗漏分析:研究发现,具有神经质遗传倾向的人群罹患早期 AMD 的风险降低了 39.7%(OR = 0.603,95% CI = 0.385-0.945,p = 0.027)。相反,具有主观幸福感遗传倾向的人群患早期老年性黄斑变性的风险增加了 3.2%(OR = 1.032,95% CI = 1.003-1.063,p = 0.029)。没有发现抑郁或对环境压力和逆境的敏感性与早期老年性黄斑变性有明显的因果关系,也没有发现早期老年性黄斑变性与心理健康有明显的因果关系:本研究提供的初步证据表明,心理健康与早期老年性视网膜病变之间的关系可能是复杂和多方面的。它表明,中等程度的神经质可能会通过健康行为、病理生理机制和其他因素降低早期 AMD 的风险,而高水平的主观幸福感可能会同样增加这种风险。然而,由于缺乏实质性证据,这些发现还不足以制定预防策略,仍需要广泛的实验研究来进一步验证。
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来源期刊
Current Eye Research
Current Eye Research 医学-眼科学
CiteScore
4.60
自引率
0.00%
发文量
163
审稿时长
12 months
期刊介绍: The principal aim of Current Eye Research is to provide rapid publication of full papers, short communications and mini-reviews, all high quality. Current Eye Research publishes articles encompassing all the areas of eye research. Subject areas include the following: clinical research, anatomy, physiology, biophysics, biochemistry, pharmacology, developmental biology, microbiology and immunology.
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