One-pot synthesis of polysaccharide/gelatin amorphous hydrogels impregnated with a bioflavonoid derived from Elaeis guineensis leaf: wound healing and drug release properties.

IF 2.5 4区 医学 Q3 PHARMACOLOGY & PHARMACY DARU Journal of Pharmaceutical Sciences Pub Date : 2024-12-01 Epub Date: 2024-09-28 DOI:10.1007/s40199-024-00540-z
Mohamad Shazeli Che Zain, Mohammed Danish, Khozirah Shaari, Sharida Fakurazi
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Abstract

Background: Amorphous hydrogel is a strategic wound healing dressings that comprised of water, polymers and excipients with no shape. The dense cross-linked network of polymer is interspersed by the immobilized water component could rehydrate and promote healing in wound tissue.

Objective: In this work, various polysaccharide/gelatin amorphous hydrogels with the impregnation of oil palm leaf derived total flavonoid enriched extract (OPL-TFEE) were fabricated via one-pot synthesis method to provide multiple crosslinking networks.

Method: The bioflavonoids (OPL-TFEE) were derived from Elaeis guineensis leaf using an integrated green extraction and enrichment process. Amorphous hydrogels with good wound healing properties were developed by incorporating 0.3% antioxidant agent into the hybrid polymeric gelling system.

Result: The formulations appeared as a semi-solid dark yellow translucent hydrogel with good spreading and consistency characteristics and satisfying aesthetic properties. The FTIR analysis indicated that the bioflavonoid was compatible with the matrix, and the hydrogels showed porous morphological structures when observed under SEM. Furthermore, the hydrogels possessed shear thinning, pseudoplastic, and elastic properties. Bioflavonoids-impregnated polysaccharide/gelatin hydrogel release 95-98% bioflavonoids within 24 h, while the drug release profile followed the Korsmeyer-Peppas kinetic model. The hydrogels showed antioxidant and wound healing properties with no sign of cytotoxicity.

Conclusion: Overall, the results revealed bioflavonoid-loaded hydrogels exhibited good physicochemical and biological properties, thus could serve as new innovative formulation in the sustainable advancement of wound care product for promoting wound healing.

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多糖/明胶无定形水凝胶的一锅合成:伤口愈合和药物释放特性。
背景:无定形水凝胶是一种战略性伤口愈合敷料,由水、聚合物和辅料组成,没有形状。聚合物的致密交联网络中夹杂着固定的水成分,可为伤口组织补充水分并促进愈合:本研究通过一锅合成法制备了浸渍油棕叶总黄酮富集提取物(OPL-TFEE)的各种多糖/明胶无定形水凝胶,以提供多重交联网络:方法:生物类黄酮(OPL-TFEE)来自油棕叶,采用绿色提取和富集一体化工艺。在混合聚合物胶凝体系中加入 0.3% 的抗氧化剂,开发出具有良好伤口愈合性能的无定形水凝胶:结果:配方呈半固态深黄色半透明水凝胶,具有良好的铺展性和稠度特性,并具有令人满意的美观特性。傅立叶变换红外分析表明,生物类黄酮与基质相容,在扫描电镜下观察,水凝胶呈现多孔形态结构。此外,水凝胶还具有剪切稀化、假塑性和弹性特性。浸渍生物类黄酮的多糖/明胶水凝胶可在 24 小时内释放 95-98% 的生物类黄酮,药物释放曲线遵循 Korsmeyer-Peppas 动力学模型。水凝胶具有抗氧化和伤口愈合特性,且无细胞毒性迹象:总之,研究结果表明,负载生物类黄酮的水凝胶具有良好的物理化学和生物学特性,因此可作为一种新型创新配方,用于促进伤口愈合的伤口护理产品的可持续发展。
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DARU Journal of Pharmaceutical Sciences
DARU Journal of Pharmaceutical Sciences PHARMACOLOGY & PHARMACY-
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期刊介绍: DARU Journal of Pharmaceutical Sciences is a peer-reviewed journal published on behalf of Tehran University of Medical Sciences. The journal encompasses all fields of the pharmaceutical sciences and presents timely research on all areas of drug conception, design, manufacture, classification and assessment. The term DARU is derived from the Persian name meaning drug or medicine. This journal is a unique platform to improve the knowledge of researchers and scientists by publishing novel articles including basic and clinical investigations from members of the global scientific community in the forms of original articles, systematic or narrative reviews, meta-analyses, letters, and short communications.
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