Eosinophilic gastrointestinal disorders and the role for the epithelium in pathogenesis and treatment.

IF 2.2 3区 医学 Q2 PEDIATRICS Current opinion in pediatrics Pub Date : 2024-12-01 Epub Date: 2024-09-20 DOI:10.1097/MOP.0000000000001406
Eric M Rodríguez-López, David A Hill
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Abstract

Purpose of review: This review aims to provide an overview of the current understanding of eosinophilic gastrointestinal disorders (EGIDs) and the role of the epithelium in influencing disease pathogenesis to inform and devise future therapeutic strategies.

Recent findings: Changes in epithelial cell structure, functions, and integrity are observed in EGIDs. In eosinophilic esophagitis (EoE), the esophageal epithelium has been shown to play key roles in perpetuating the inflammatory response in EoE through the expression of pro-inflammatory cytokines and immunological cell-surface proteins. Similar mechanisms appear to exist in the other EGIDs, including eosinophilic gastritis (EoG), eosinophilic enteritis (EoN), and eosinophilic colitis (EoC). Because of the increasing rarity of each non-EoE EGID, research focusing on how the epithelium is modulating disease in each lower gastrointestinal compartment is still in its rudimentary stages.

Summary: While there has been significant progress in understanding the role of the epithelium in EoE, further research is needed to obtain a better understanding of the mechanisms mediating epithelial-immune crosstalk in non-EoE EGIDs. Using EoE-epithelial cell research to inform future EGID investigations could lead to the development of new therapeutic interventions, such as targeted therapies to restore epithelial barrier function and reduce inflammation, to improve rare disease-patient quality of life.

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嗜酸性粒细胞胃肠道疾病以及上皮细胞在发病和治疗中的作用。
综述目的:本综述旨在概述目前对嗜酸性粒细胞性胃肠病(EGIDs)的认识以及上皮细胞在影响疾病发病机制中的作用,从而为未来的治疗策略提供参考:最新发现:在 EGIDs 中可观察到上皮细胞结构、功能和完整性的变化。在嗜酸性粒细胞食管炎(EoE)中,食管上皮细胞通过表达促炎细胞因子和免疫细胞表面蛋白,在延续 EoE 的炎症反应中发挥着关键作用。嗜酸性粒细胞性胃炎(EoG)、嗜酸性粒细胞性肠炎(EoN)和嗜酸性粒细胞性结肠炎(EoC)等其他 EGID 似乎也存在类似的机制。摘要:虽然在了解上皮在嗜酸性粒细胞增多症中的作用方面取得了重大进展,但要更好地了解非嗜酸性粒细胞增多症的上皮-免疫串扰机制,还需要进一步的研究。利用咽鼓管上皮细胞研究为未来的 EGID 研究提供信息,可以开发出新的治疗干预措施,如恢复上皮屏障功能和减少炎症的靶向疗法,从而改善罕见病患者的生活质量。
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来源期刊
CiteScore
6.20
自引率
0.00%
发文量
184
审稿时长
6-12 weeks
期刊介绍: ​​​​​Current Opinion in Pediatrics is a reader-friendly resource which allows the reader to keep up-to-date with the most important advances in the pediatric field. Each issue of Current Opinion in Pediatrics contains three main sections delivering a diverse and comprehensive cover of all key issues related to pediatrics; including genetics, therapeutics and toxicology, adolescent medicine, neonatology and perinatology, and orthopedics. Unique to Current Opinion in Pediatrics is the office pediatrics section which appears in every issue and covers popular topics such as fever, immunization and ADHD. Current Opinion in Pediatrics is an indispensable journal for the busy clinician, researcher or student.
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