Modification of natural compounds through biotransformation process by microorganisms and their pharmacological properties

IF 2.5 3区医学 Q3 CHEMISTRY, MEDICINAL Fitoterapia Pub Date : 2024-09-24 DOI:10.1016/j.fitote.2024.106227

Nigora Rustamova , Guozheng Huang , Maksud Isokov , Jakhongir Movlanov , Ruziev Farid , Islamov Buston , Hua Xiang , Kahramon Davranov , Abulimiti Yili

{"title":"Modification of natural compounds through biotransformation process by microorganisms and their pharmacological properties","authors":"Nigora Rustamova , Guozheng Huang , Maksud Isokov , Jakhongir Movlanov , Ruziev Farid , Islamov Buston , Hua Xiang , Kahramon Davranov , Abulimiti Yili","doi":"10.1016/j.fitote.2024.106227","DOIUrl":null,"url":null,"abstract":"<div><div>The biotransformation of natural compounds by fungal microorganisms is a complex biochemical process. Tandem whole-cell biotransformation offers a promising, alternative, and cost-effective method for modifying of bioactive novel compounds. This approach is particularly beneficial for structurally complex natural products that are difficult to be synthesized through traditional synthetic methods. Biotransformation also provides significant regio- and stereoselectivity, making it a valuable tool for the chemical modification of natural compounds. By utilizing microbial conversion reactions, the biological activity and structural diversity of natural products can be enhanced. In this review, we have summarized 282 novel metabolites resulting from microbial transformation by various microorganisms. We discussed the chemical structures and pharmacological properties of these novel biotransformation products. The review would assist scientists working in the fields of biotechnology, organic chemistry, medicinal chemistry, and pharmacology.</div></div>","PeriodicalId":12147,"journal":{"name":"Fitoterapia","volume":"179 ","pages":"Article 106227"},"PeriodicalIF":2.5000,"publicationDate":"2024-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Fitoterapia","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0367326X24004106","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"CHEMISTRY, MEDICINAL","Score":null,"Total":0}

引用次数: 0

Abstract

The biotransformation of natural compounds by fungal microorganisms is a complex biochemical process. Tandem whole-cell biotransformation offers a promising, alternative, and cost-effective method for modifying of bioactive novel compounds. This approach is particularly beneficial for structurally complex natural products that are difficult to be synthesized through traditional synthetic methods. Biotransformation also provides significant regio- and stereoselectivity, making it a valuable tool for the chemical modification of natural compounds. By utilizing microbial conversion reactions, the biological activity and structural diversity of natural products can be enhanced. In this review, we have summarized 282 novel metabolites resulting from microbial transformation by various microorganisms. We discussed the chemical structures and pharmacological properties of these novel biotransformation products. The review would assist scientists working in the fields of biotechnology, organic chemistry, medicinal chemistry, and pharmacology.

Abstract Image

查看原文

微信好友朋友圈 QQ好友复制链接

本刊更多论文

微生物通过生物转化过程改变天然化合物及其药理特性。

真菌微生物对天然化合物的生物转化是一个复杂的生化过程。串联全细胞生物转化为改造具有生物活性的新型化合物提供了一种前景广阔、可供选择且具有成本效益的方法。这种方法尤其适用于难以通过全化学合成方法合成的结构复杂的天然产品。生物转化还具有显著的区域和立体选择性，使其成为天然化合物化学修饰的重要工具。利用微生物转化反应，可以提高天然产物的生物活性和结构多样性。在这篇综述中，我们总结了各种微生物通过微生物转化产生的 282 种新型代谢物。我们讨论了这些新型生物转化产物的化学结构和药理特性。本综述旨在为生物技术、有机化学、药物化学和药理学领域的科学家提供帮助。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文去求助

来源期刊

Fitoterapia 医学-药学

CiteScore

5.80

自引率

2.90%

发文量

198

审稿时长

1.5 months

期刊介绍： Fitoterapia is a Journal dedicated to medicinal plants and to bioactive natural products of plant origin. It publishes original contributions in seven major areas: 1. Characterization of active ingredients of medicinal plants 2. Development of standardization method for bioactive plant extracts and natural products 3. Identification of bioactivity in plant extracts 4. Identification of targets and mechanism of activity of plant extracts 5. Production and genomic characterization of medicinal plants biomass 6. Chemistry and biochemistry of bioactive natural products of plant origin 7. Critical reviews of the historical, clinical and legal status of medicinal plants, and accounts on topical issues.