IL-10: the master immunomodulatory cytokine in allergen immunotherapy.

IF 3.9 3区医学 Q2 IMMUNOLOGY Expert Review of Clinical Immunology Pub Date : 2024-09-25 DOI:10.1080/1744666X.2024.2406894

Shixian Liu, Jingyun Li, Yuan Zhang, Chengshuo Wang, Luo Zhang

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Abstract

Introduction: Allergen immunotherapy (AIT) is the only disease-modifying treatment for patients with IgE-mediated allergic diseases. Successful AIT can induce long-term immune tolerance to the common allergen, which provides clinical benefits for years after discontinuation. The cytokine interleukin (IL)-10, as a key anti-inflammatory mediator with strong immunoregulatory functions, has drawn increasing attention over the past decades.

Areas covered: After an extensive search of PubMed, EMBASE, and Web of Science databases, covering articles published from 1989 to 2024, our review aims to emphasize the key common information from previous reviews on the crucial involvement of IL-10 in allergen immunotherapy (AIT) induced immunological tolerance. In this review, we discuss the regulation of IL-10 expression and the molecular pathways associated with IL-10 function. We also further summarize mechanisms of immune tolerance induced by AIT, especially the indispensable role of IL-10 in AIT.

Expert opinion: IL-10 plays an indispensable role in immune tolerance induced by AIT. Understanding the importance of the role of IL-10 in AIT would help us comprehend the mechanisms thoroughly and develop targeted therapeutics for allergic diseases.

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IL-10：过敏原免疫疗法中的主要免疫调节细胞因子。

简介：过敏原免疫疗法（AIT）是针对 IgE 介导的过敏性疾病患者的唯一可改变病情的治疗方法。成功的过敏原免疫疗法可诱导患者对常见过敏原产生长期免疫耐受，从而在停药后数年内仍能获得临床疗效。细胞因子白细胞介素（IL）-10作为一种关键的抗炎介质，具有很强的免疫调节功能，在过去的几十年中引起了越来越多的关注：经过对 PubMed、EMBASE 和 Web of Science 数据库的广泛检索，我们的综述涵盖了从 1989 年到 2024 年发表的文章，旨在强调以往综述中关于 IL-10 在过敏原免疫疗法（AIT）诱导的免疫耐受中的重要参与的关键共同信息。在这篇综述中，我们讨论了 IL-10 的表达调控以及与 IL-10 功能相关的分子通路。我们还进一步总结了AIT诱导免疫耐受的机制，尤其是IL-10在AIT中不可或缺的作用：IL-10在AIT诱导的免疫耐受中发挥着不可或缺的作用。专家观点：IL-10在AIT诱导的免疫耐受中发挥着不可或缺的作用。了解IL-10在AIT中的重要作用有助于我们深入理解其机制，并开发出治疗过敏性疾病的靶向疗法。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Expert Review of Clinical Immunology IMMUNOLOGY-

CiteScore

7.60

自引率

2.30%

发文量

221

审稿时长

6-12 weeks

期刊介绍： Expert Review of Clinical Immunology (ISSN 1744-666X) provides expert analysis and commentary regarding the performance of new therapeutic and diagnostic modalities in clinical immunology. Members of the International Editorial Advisory Panel of Expert Review of Clinical Immunology are the forefront of their area of expertise. This panel works with our dedicated editorial team to identify the most important and topical review themes and the corresponding expert(s) most appropriate to provide commentary and analysis. All articles are subject to rigorous peer-review, and the finished reviews provide an essential contribution to decision-making in clinical immunology. Articles focus on the following key areas: • Therapeutic overviews of specific immunologic disorders highlighting optimal therapy and prospects for new medicines • Performance and benefits of newly approved therapeutic agents • New diagnostic approaches • Screening and patient stratification • Pharmacoeconomic studies • New therapeutic indications for existing therapies • Adverse effects, occurrence and reduction • Prospects for medicines in late-stage trials approaching regulatory approval • Novel treatment strategies • Epidemiological studies • Commentary and comparison of treatment guidelines Topics include infection and immunity, inflammation, host defense mechanisms, congenital and acquired immunodeficiencies, anaphylaxis and allergy, systemic immune diseases, organ-specific inflammatory diseases, transplantation immunology, endocrinology and diabetes, cancer immunology, neuroimmunology and hematological diseases.