Oocyte Quality in Women with Endometriosis.

IF 2 4区 医学 Q2 OBSTETRICS & GYNECOLOGY Gynecologic and Obstetric Investigation Pub Date : 2024-09-30 DOI:10.1159/000541615
Rafael Trinchant, Juan Antonio García-Velasco
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引用次数: 0

Abstract

Background: Endometriosis is a chronic gynecological condition that affects approximately 10% of women of reproductive age globally. It is associated with significant morbidity due to symptoms such as pelvic pain and infertility. Current knowledge suggests that endometriosis impacts oocyte quality, a critical factor for successful fertilization and pregnancy. Despite extensive research, the exact mechanisms remain unclear, and further updates are necessary to optimize treatment strategies.

Objectives: This review aims to summarize current evidence regarding the impact of endometriosis on oocyte quality and its subsequent effects on fertility outcomes, particularly in the context of in vitro fertilization (IVF).

Methods: A comprehensive search was conducted in PubMed using the terms "endometriosis AND oocyte quality," "endometriosis AND infertility, and "endometriosis AND IVF." The review included studies published up to July 2024.

Outcome: The review findings indicate that endometriosis may be associated with decreased oocyte quality, characterized by impaired morphological features and molecular abnormalities. These defects potentially lead to lower fertilization rates, impaired embryo development, and reduced pregnancy outcomes. However, some studies suggest that with controlled factors such as age and ovarian reserve, IVF outcomes may be comparable to those without endometriosis.

Conclusions and outlook: For clinicians and scientists working in medically assisted reproduction, understanding the impact of endometriosis on oocyte quality is crucial for improving fertility treatment outcomes. Advances in assisted reproductive technologies and personalized treatment approaches may mitigate these adverse effects. The potential for using artificial intelligence to assess oocyte quality presents a promising avenue for future research, as currently there is no direct and objective measure to assess this parameter.

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子宫内膜异位症妇女的卵母细胞质量。
背景 子宫内膜异位症是一种慢性妇科疾病,影响着全球约 10% 的育龄妇女。由于盆腔疼痛和不孕等症状,子宫内膜异位症的发病率很高。目前的研究表明,子宫内膜异位症会影响卵母细胞质量,而卵母细胞质量是成功受精和怀孕的关键因素。尽管进行了广泛的研究,但确切的机制仍不清楚,因此有必要进一步更新,以优化治疗策略。目的 本综述旨在总结有关子宫内膜异位症对卵母细胞质量的影响及其对生育结果的后续影响的现有证据,尤其是在体外受精(IVF)的情况下。方法 使用 "子宫内膜异位症与卵母细胞质量"、"子宫内膜异位症与不孕症 "和 "子宫内膜异位症与体外受精 "等词在 PubMed 上进行了全面检索。综述包括截至 2024 年 7 月发表的研究。综述结果综述结果表明,子宫内膜异位症可能与卵母细胞质量下降有关,其特征是形态特征受损和分子异常。这些缺陷可能会导致受精率降低、胚胎发育受损和妊娠结局减少。然而,一些研究表明,在控制年龄和卵巢储备等因素的情况下,试管婴儿的结果可能与无子宫内膜异位症的患者相当。结论与展望 对于从事医学辅助生殖的临床医生和科学家来说,了解子宫内膜异位症对卵母细胞质量的影响对于改善生育治疗效果至关重要。辅助生殖技术和个性化治疗方法的进步可能会减轻这些不利影响。使用人工智能评估卵母细胞质量的潜力为未来的研究提供了一个前景广阔的途径,因为目前还没有直接客观的方法来评估这一参数。
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来源期刊
CiteScore
4.20
自引率
4.80%
发文量
44
审稿时长
6-12 weeks
期刊介绍: This journal covers the most active and promising areas of current research in gynecology and obstetrics. Invited, well-referenced reviews by noted experts keep readers in touch with the general framework and direction of international study. Original papers report selected experimental and clinical investigations in all fields related to gynecology, obstetrics and reproduction. Short communications are published to allow immediate discussion of new data. The international and interdisciplinary character of this periodical provides an avenue to less accessible sources and to worldwide research for investigators and practitioners.
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