The German research consortium for the study of bipolar disorder (BipoLife): a quality assurance protocol for MR neuroimaging data.

IF 2.8 2区 医学 Q2 PSYCHIATRY International Journal of Bipolar Disorders Pub Date : 2024-09-26 DOI:10.1186/s40345-024-00354-7
Christoph Vogelbacher, Jens Sommer, Miriam H A Bopp, Irina Falkenberg, Philipp S Ritter, Felix Bermpohl, Catherine Hindi Attar, Karolin E Einenkel, Oliver Gruber, Georg Juckel, Vera Flasbeck, Martin Hautzinger, Andrea Pfennig, Silke Matura, Andreas Reif, Dominik Grotegerd, Udo Dannlowski, Tilo Kircher, Michael Bauer, Andreas Jansen
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Abstract

Background: The German multicenter research consortium BipoLife aims to investigate the mechanisms underlying bipolar disorders. It focuses in particular on people at high risk of developing the disorder and young patients in the early stages of the disease. Functional and structural magnetic resonance imaging (MRI) data was collected in all participating centers. The collection of neuroimaging data in a longitudinal, multicenter study requires the implementation of a comprehensive quality assurance (QA) protocol. Here, we outline this protocol and illustrate its application within the BipoLife consortium.

Methods: The QA protocol consisted of (1) a training of participating research staff, (2) regular phantom measurements to evaluate the MR scanner performance and its temporal stability across the course of the study, and (3) the assessment of the quality of human MRI data by evaluating a variety of image metrics (e.g., signal-to-noise ratio, ghosting level). In this article, we will provide an overview on these QA procedures and show exemplarily the influence of its application on the results of standard neuroimaging analysis pipelines.

Discussion: The QA protocol helped to characterize the various MR scanners, to record their performance over the course of the study and to detect possible malfunctions at an early stage. It also assessed the quality of the human MRI data systematically to characterize its influence on various analyses. Furthermore, by setting up and publishing this protocol, we define standards that must be considered when analyzing data from the BipoLife consortium. It further promotes a systematic evaluation of data quality and a definition of subject inclusion criteria. In the long term, it will help to increase the chance of achieving clinically relevant results.

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德国双相情感障碍研究联盟(BipoLife):磁共振神经成像数据质量保证协议。
背景:德国多中心研究联盟 BipoLife 旨在研究躁郁症的发病机制。它特别关注躁郁症的高危人群和处于疾病早期阶段的年轻患者。所有参与中心都收集了功能和结构磁共振成像(MRI)数据。在纵向多中心研究中收集神经成像数据需要实施全面的质量保证(QA)方案。在此,我们概述了这一方案,并说明了其在 BipoLife 联合体中的应用:质量保证方案包括:(1) 对参与研究的人员进行培训;(2) 定期进行模型测量,以评估 MR 扫描仪的性能及其在整个研究过程中的时间稳定性;(3) 通过评估各种图像指标(如信噪比、重影水平)来评估人体 MRI 数据的质量。在本文中,我们将概述这些质量保证程序,并举例说明其应用对标准神经成像分析管道结果的影响:质量保证协议有助于确定各种磁共振扫描仪的特性,记录它们在研究过程中的表现,并及早发现可能出现的故障。它还系统地评估了人体磁共振成像数据的质量,以确定其对各种分析的影响。此外,通过制定和发布该协议,我们定义了分析 BipoLife 联合体数据时必须考虑的标准。它进一步促进了对数据质量的系统评估和受试者纳入标准的定义。从长远来看,这将有助于增加获得临床相关结果的机会。
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来源期刊
International Journal of Bipolar Disorders
International Journal of Bipolar Disorders Medicine-Psychiatry and Mental Health
CiteScore
6.70
自引率
5.00%
发文量
26
审稿时长
13 weeks
期刊介绍: The International Journal of Bipolar Disorders is a peer-reviewed, open access online journal published under the SpringerOpen brand. It publishes contributions from the broad range of clinical, psychological and biological research in bipolar disorders. It is the official journal of the ECNP-ENBREC (European Network of Bipolar Research Expert Centres ) Bipolar Disorders Network, the International Group for the study of Lithium Treated Patients (IGSLi) and the Deutsche Gesellschaft für Bipolare Störungen (DGBS) and invites clinicians and researchers from around the globe to submit original research papers, short research communications, reviews, guidelines, case reports and letters to the editor that help to enhance understanding of bipolar disorders.
期刊最新文献
Aripiprazole once-monthly for the treatment of adult patients with earlier-stage bipolar I disorder: a post hoc analysis of data from a double-blind, placebo-controlled, 52-week randomized withdrawal trial. Correction: Effectiveness of ultra-long-term lithium treatment: relevant factors and case series. Relevance of red blood cell Lithium concentration in the management of Lithium-treated bipolar and unipolar disorders: a systematic narrative review. Perceived cognitive loss, symptomology, and psychological well-being with bipolar disorder. The German research consortium for the study of bipolar disorder (BipoLife): a quality assurance protocol for MR neuroimaging data.
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