Genetic diversity and potential transmission of Escherichia albertii in a poultry breeding rural village.

IF 1.3 4区 医学 Q4 INFECTIOUS DISEASES Japanese journal of infectious diseases Pub Date : 2024-09-30 DOI:10.7883/yoken.JJID.2024.209
Peihua Zhang, Guodong Yan, Qian Liu, Xi Yang, Jie Zhang, Xi Chen, Hong Wang, Ling Zhang, Xinxia Sui, Xiangning Bai, Yanwen Xiong, Zhengdong Zhang
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Abstract

Escherichia albertii is an emerging foodborne pathogen causing diarrhea. Though various animals, especially poultry, serve as reservoirs, the transmission of E. albertii among reservoirs and the risk to humans remain unclear. This study investigated an E. albertii infected infant with poultry exposure and collected samples from contact persons, poultries, and environment to better understand the transmission dynamics of E. albertii. One E. albertii isolate from contact person, seven isolates from poultries, and six isolates from environment were recovered, respectively. Whole genome sequencing analysis showed that eight strains derived from poultry or environment and classified as ST4633, shared great similarity (cgSNP ≤ 20). However, the patient-derived strain ESA311 had a cgSNP difference of 1165 with human strain ESA339, and differed from poultry and environmental strains (cgSNP range 2417 to 14997), suggesting a distant relatedness. Whole genome phylogeny showed several human-derived E. albertii strains were clustered with those from animal origins. Our results suggested that family-breeding poultry constituted a possible reservoir of E. albertii, with the environment acting as a crucial vector for the spread of these bacteria, posing a risk to humans. Further poultry surveillance is needed to elucidate public health risks associated with E. albertii infection.

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一个家禽养殖农村的白细胞埃希氏菌遗传多样性和潜在传播途径。
白喉杆菌是一种新出现的食源性病原体,可引起腹泻。虽然各种动物(尤其是家禽)都是白喉杆菌的宿主,但白喉杆菌在宿主之间的传播以及对人类的风险仍不清楚。本研究调查了一名因接触家禽而感染白喉杆菌的婴儿,并从接触者、家禽饲养场和环境中采集样本,以更好地了解白喉杆菌的传播动态。研究分别从接触者、家禽饲养场和环境中分离出了 1 株白喉杆菌、7 株和 6 株。全基因组测序分析表明,8 株来自家禽或环境的菌株被归类为 ST4633,它们具有很大的相似性(cgSNP ≤ 20)。然而,患者来源的菌株ESA311与人类菌株ESA339的cgSNP相差1165,与家禽和环境菌株的cgSNP范围(2417至14997)不同,这表明两者之间存在远缘关系。全基因组系统发育显示,一些来自人类的白喉杆菌菌株与来自动物的菌株聚集在一起。我们的研究结果表明,家庭饲养的家禽可能是白喉杆菌的贮藏库,环境是这些细菌传播的重要媒介,对人类构成风险。需要对家禽进行进一步监测,以阐明与白喉杆菌感染相关的公共卫生风险。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
4.50
自引率
4.50%
发文量
172
审稿时长
2 months
期刊介绍: Japanese Journal of Infectious Diseases (JJID), an official bimonthly publication of National Institute of Infectious Diseases, Japan, publishes papers dealing with basic research on infectious diseases relevant to humans in the fields of bacteriology, virology, mycology, parasitology, medical entomology, vaccinology, and toxinology. Pathology, immunology, biochemistry, and blood safety related to microbial pathogens are among the fields covered. Sections include: original papers, short communications, epidemiological reports, methods, laboratory and epidemiology communications, letters to the editor, and reviews.
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