The Mitochondrial Transplantation: A New Frontier in Plastic Surgery.

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY Accounts of Chemical Research Pub Date : 2024-09-30 DOI:10.1097/SCS.0000000000010706

Haoran Li, Dali Mu

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Abstract

Challenges such as difficult wound healing, ischemic necrosis of skin flaps, and skin aging are prevalent in plastic surgery. Previous research has indeed suggested that these challenges in plastic surgery are often linked to cellular energy barriers. As the powerhouses of the cell, mitochondria play a critical role in sustaining cellular vitality and health. Fundamentally, issues like ischemic and hypoxic damage to organs and tissues, as well as aging, stem from mitochondrial dysfunction, which leads to a depletion of cellular energy. Hence, having an adequate number of high-quality, healthy mitochondria is vital for maintaining tissue stability and cell survival. In recent years, there has been preliminary exploration into the protective effects of mitochondrial transplantation against cellular damage in systems such as the nervous, cardiovascular, and respiratory systems. For plastic surgery, mitochondrial transplantation is an extremely advanced research topic. This review focuses on the novel applications and future prospects of mitochondrial transplantation in plastic surgery, providing insights for clinicians and researchers, and offering guidance to patients seeking innovative and effective treatment options.

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线粒体移植：整形外科的新领域。

伤口愈合困难、皮瓣缺血坏死和皮肤老化等难题在整形外科中普遍存在。以往的研究表明，整形外科面临的这些挑战往往与细胞能量障碍有关。线粒体作为细胞的动力源，在维持细胞活力和健康方面发挥着至关重要的作用。从根本上说，器官和组织的缺血缺氧损伤以及衰老等问题都源于线粒体功能障碍，它导致细胞能量耗竭。因此，拥有足够数量的高质量健康线粒体对于维持组织稳定和细胞存活至关重要。近年来，人们已初步探索了线粒体移植对神经、心血管和呼吸系统等系统的细胞损伤的保护作用。对于整形外科来说，线粒体移植是一个极为先进的研究课题。这篇综述主要介绍线粒体移植在整形外科中的新应用和未来前景，为临床医生和研究人员提供见解，并为寻求创新和有效治疗方案的患者提供指导。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.