IFN-γ and YAP lead epithelial cells astray after severe respiratory infection.

IF 13.3 1区 医学 Q1 MEDICINE, RESEARCH & EXPERIMENTAL Journal of Clinical Investigation Pub Date : 2024-10-01 DOI:10.1172/JCI185072
Bradley E Hiller, Joseph P Mizgerd
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Abstract

Ineffective recovery from pneumonia can lead to interstitial lung disease characterized by aberrant epithelial cells in fibrotic regions. In this issue of the JCI, Lin et al. define molecular pathways leading to the development and persistence of keratin 5+ (Krt5+) epithelial cells in the alveolar parenchyma when mice struggle to recover from influenza infection. The receptor for IFN-γ on lung epithelium was essential for the formation of aberrant Krt5+ cells and fibrotic lung disease. The transcription factor Yes-associated protein 1 (YAP) was necessary for persistence of these Krt5+ cells, and IFN-γ activated YAP in lung epithelial cells via JAK, focal adhesion kinase (FAK), and Src kinases. These findings establish a targetable pathway underlying some of the pulmonary postacute sequelae of pneumonia.

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严重呼吸道感染后,IFN-γ 和 YAP 将上皮细胞引入歧途。
肺炎恢复不佳会导致间质性肺病,其特征是纤维化区域出现异常上皮细胞。在本期 JCI 杂志上,Lin 等人明确了当小鼠从流感感染中挣扎着恢复时,导致角蛋白 5+(Krt5+)上皮细胞在肺泡实质中发育和持续存在的分子途径。肺上皮细胞上的IFN-γ受体对异常Krt5+细胞的形成和肺纤维化疾病至关重要。转录因子Yes相关蛋白1(YAP)是这些Krt5+细胞持续存在的必要条件,IFN-γ通过JAK、局灶粘附激酶(FAK)和Src激酶激活肺上皮细胞中的YAP。这些发现为肺炎急性后遗症的某些肺部病变提供了一个靶向途径。
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来源期刊
Journal of Clinical Investigation
Journal of Clinical Investigation 医学-医学:研究与实验
CiteScore
24.50
自引率
1.30%
发文量
1034
审稿时长
2 months
期刊介绍: The Journal of Clinical Investigation, established in 1924 by the ASCI, is a prestigious publication that focuses on breakthroughs in basic and clinical biomedical science, with the goal of advancing the field of medicine. With an impressive Impact Factor of 15.9 in 2022, it is recognized as one of the leading journals in the "Medicine, Research & Experimental" category of the Web of Science. The journal attracts a diverse readership from various medical disciplines and sectors. It publishes a wide range of research articles encompassing all biomedical specialties, including Autoimmunity, Gastroenterology, Immunology, Metabolism, Nephrology, Neuroscience, Oncology, Pulmonology, Vascular Biology, and many others. The Editorial Board consists of esteemed academic editors who possess extensive expertise in their respective fields. They are actively involved in research, ensuring the journal's high standards of publication and scientific rigor.
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