Sleepless nights and social plights: medial septum GABAergic hyperactivity in a neuroligin 3-deficient autism model.

IF 13.3 1区 医学 Q1 MEDICINE, RESEARCH & EXPERIMENTAL Journal of Clinical Investigation Pub Date : 2024-10-01 DOI:10.1172/JCI184795
Claire E Cho, Dahee Jung, Reesha R Patel
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Abstract

Social deficits represent a core symptom domain of autism spectrum disorder (ASD), which is often comorbid with sleep disturbances. In this issue of the JCI, Sun et al. explored a medial septum (MS) circuit linking these behaviors in a neuroligin 3 conditional knockout model of autism. They identified GABAergic neuron hyperactivity following neuroligin 3 deletion in the MS. This hyperactivity resulted in the inhibition of the downstream preoptic area (POA) and hippocampal CA2 region, resulting in sleep loss and social memory deficits, respectively. Inactivating the hyperactive MS GABA neurons or activating the POA or CA2 rescued the behavioral deficits. Together, these findings deepen our understanding of neural circuits underlying social and sleep deficits in ASD.

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不眠之夜与社交困境:神经胶质蛋白 3 缺陷自闭症模型的内侧隔 GABA 能亢进。
社交障碍是自闭症谱系障碍(ASD)的一个核心症状领域,通常与睡眠障碍并发。在本期 JCI 杂志上,Sun 等人在神经胶质蛋白 3 条件性基因敲除的自闭症模型中探索了连接这些行为的内隔膜(MS)回路。他们在 MS 中发现了神经胶质蛋白 3 缺失后的 GABA 能神经元亢进。这种亢进导致下游视前区(POA)和海马 CA2 区受到抑制,分别造成睡眠丧失和社会记忆缺陷。使过度活跃的MS GABA神经元失活,或激活POA或CA2,都能挽救行为缺陷。这些发现加深了我们对 ASD 社交和睡眠障碍神经回路的理解。
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来源期刊
Journal of Clinical Investigation
Journal of Clinical Investigation 医学-医学:研究与实验
CiteScore
24.50
自引率
1.30%
发文量
1034
审稿时长
2 months
期刊介绍: The Journal of Clinical Investigation, established in 1924 by the ASCI, is a prestigious publication that focuses on breakthroughs in basic and clinical biomedical science, with the goal of advancing the field of medicine. With an impressive Impact Factor of 15.9 in 2022, it is recognized as one of the leading journals in the "Medicine, Research & Experimental" category of the Web of Science. The journal attracts a diverse readership from various medical disciplines and sectors. It publishes a wide range of research articles encompassing all biomedical specialties, including Autoimmunity, Gastroenterology, Immunology, Metabolism, Nephrology, Neuroscience, Oncology, Pulmonology, Vascular Biology, and many others. The Editorial Board consists of esteemed academic editors who possess extensive expertise in their respective fields. They are actively involved in research, ensuring the journal's high standards of publication and scientific rigor.
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