Effect of Silica Nanoparticle Treatment on Adhesion between Tissue-like Substrates and In Vivo Skin Wound Sealing.

IF 5 3区医学 Q1 ENGINEERING, BIOMEDICAL Journal of Functional Biomaterials Pub Date : 2024-09-09 DOI:10.3390/jfb15090259

Yeji Jeon, Tae Ryeol Kim, Eun Seo Park, Jae Hyun Park, Han Sung Youn, Dae Youn Hwang, Sungbaek Seo

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Abstract

Silica nanoparticles are innovative solutions of surgical glue that can readily adhere to various tissue-like substrates without the need for time-consuming chemical reactions or ultraviolet irradiation. Herein, 10 nm-sized silica nanoparticle (SiNP₁₀) treatment exhibited maximum adhesion strength in the porcine heart tissue model, which was approximately 7.15 times higher than that of the control group of non-treatment. We assessed the effects of silica nanoparticle treatment on in vivo skin wounds by scoring tissue adhesion and inflammation using histological images. Compared to the commercial cyanoacrylate skin adhesive (Dermabond), suppression of inflammatory cytokine levels in the incision wound skin was observed. We further quantified the expression of angiogenic growth factors and connective tissue formation-related proteins. On day 5 after wound closing treatment, the expression levels of PDGF-BB growth factor were significantly higher in SiNP₁₀ treatment (0.64 ± 0.03) compared to Dermabond (0.07 ± 0.05). This stimulated angiogenesis and connective tissue formation in the skin of the incision wound may be associated with the promoting effects of SiNP₁₀ treatment on wound closure and tissue adhesion.

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二氧化硅纳米颗粒处理对组织样基质间粘附力和体内皮肤伤口密封性的影响

二氧化硅纳米粒子是一种创新的手术胶水解决方案，无需耗时的化学反应或紫外线照射，即可轻松粘附到各种组织基质上。在这里，10 nm 大小的二氧化硅纳米粒子（SiNP10）处理组在猪心组织模型中表现出最大粘附强度，是未处理对照组的约 7.15 倍。我们通过组织学图像对组织粘附和炎症进行评分，评估了二氧化硅纳米粒子处理对体内皮肤伤口的影响。与商用氰基丙烯酸酯皮肤粘合剂（Dermabond）相比，我们观察到切口皮肤中的炎症细胞因子水平受到抑制。我们进一步量化了血管生成生长因子和结缔组织形成相关蛋白的表达。伤口闭合处理后第 5 天，SiNP10 处理中 PDGF-BB 生长因子的表达水平（0.64 ± 0.03）明显高于 Dermabond（0.07 ± 0.05）。这刺激了切口皮肤的血管生成和结缔组织形成，可能与 SiNP10 对伤口闭合和组织粘附的促进作用有关。

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来源期刊

Journal of Functional Biomaterials Engineering-Biomedical Engineering

CiteScore

4.60

自引率

4.20%

发文量

226

审稿时长

11 weeks

期刊介绍： Journal of Functional Biomaterials (JFB, ISSN 2079-4983) is an international and interdisciplinary scientific journal that publishes regular research papers (articles), reviews and short communications about applications of materials for biomedical use. JFB covers subjects from chemistry, pharmacy, biology, physics over to engineering. The journal focuses on the preparation, performance and use of functional biomaterials in biomedical devices and their behaviour in physiological environments. Our aim is to encourage scientists to publish their results in as much detail as possible. Therefore, there is no restriction on the length of the papers. The full experimental details must be provided so that the results can be reproduced. Several topical special issues will be published. Scope: adhesion, adsorption, biocompatibility, biohybrid materials, bio-inert materials, biomaterials, biomedical devices, biomimetic materials, bone repair, cardiovascular devices, ceramics, composite materials, dental implants, dental materials, drug delivery systems, functional biopolymers, glasses, hyper branched polymers, molecularly imprinted polymers (MIPs), nanomedicine, nanoparticles, nanotechnology, natural materials, self-assembly smart materials, stimuli responsive materials, surface modification, tissue devices, tissue engineering, tissue-derived materials, urological devices.