Efficacy and safety of Supine Daoyin in the treatment of acute exacerbation of chronic obstructive pulmonary disease: A randomized controlled trial

IF 3.6 2区 医学 Q1 MEDICINE, GENERAL & INTERNAL Journal of Evidence‐Based Medicine Pub Date : 2024-09-25 DOI:10.1111/jebm.12650
Jiansheng Li, Hailong Zhang, Jun Wang, Xuechao Lu, Mingyan Zuo, Li Jiao, Xiaofan Lu, Yang Wang
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Abstract

Aim

This study aimed to develop and evaluate the efficacy and safety of Supine Daoyin, a TCM PR technique, in hospitalized patients with AECOPD.

Methods

This is a multicenter, prospective, randomized, controlled trial involving AECOPD inpatients recruited from April 2021 to December 2023 in five tertiary hospitals in China. Participants were randomly assigned to 14 days of Supine Daoyin group or control group and evaluated at days 3, 7, and 14 (posttreatment). The primary outcomes were LOS and CCQ and secondary outcomes were 6MWD, 30-STS, BI, Borg CR10, time on mechanical ventilation, SGRQ, mCOPD-PRO, and mESQ-COPD.

Results

Out of 369 participants screened, 228 were randomly assigned (Supine Daoyin group: n = 114; control group: n = 114). For primary outcomes, there was no significant between-group difference in LOS (p > 0.05), but for CCQ the Supine Daoyin was superior to control at days 7 (p < 0.01) and 14 (p < 0.01). For secondary outcomes, Supine Daoyin groups showed robust and superior improvements in 6MWD, 30-STS, BI, Borg CR10, SGRQ, mCOPD-PRO, and mESQ-COPD (all p < 0.05), but for time on mechanical ventilation there was no significant difference in two groups (p > 0.05).

Conclusion

Supine Daoyin, a novel TCM PR technique, demonstrates safety and efficacy for AECOPD inpatients, yielding clinically meaningful improvements in health status, exercise capacity, and quality of life. This study offers a viable PR option for AECOPD patients with severe symptoms and limited mobility.

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仰卧位导引术治疗慢性阻塞性肺疾病急性加重期的有效性和安全性:随机对照试验。
目的:本研究旨在开发和评估中医公关技术--仰卧位导引术在AECOPD住院患者中的疗效和安全性:本研究是一项多中心、前瞻性、随机对照试验,涉及 2021 年 4 月至 2023 年 12 月期间在中国 5 家三级医院招募的 AECOPD 住院患者。参与者被随机分配到为期 14 天的仰卧位道意组或对照组,并在第 3、7 和 14 天(治疗后)进行评估。主要结果为LOS和CCQ,次要结果为6MWD、30-STS、BI、Borg CR10、机械通气时间、SGRQ、mCOPD-PRO和mESQ-COPD:在筛选出的 369 名参与者中,228 人被随机分配(仰卧位叩齿组:n = 114;对照组:n = 114)。在主要结果方面,LOS 组间无显著差异(P > 0.05),但在第 7 天的 CCQ 方面,Supine Daoyin 组优于对照组(P 0.05):结论: Supine Daoyin 是一种新颖的中医 PR 技术,对 AECOPD 住院患者具有安全性和有效性,在健康状况、运动能力和生活质量方面都取得了有临床意义的改善。这项研究为症状严重、行动不便的 AECOPD 患者提供了一种可行的 PR 方案。
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来源期刊
Journal of Evidence‐Based Medicine
Journal of Evidence‐Based Medicine MEDICINE, GENERAL & INTERNAL-
CiteScore
11.20
自引率
1.40%
发文量
42
期刊介绍: The Journal of Evidence-Based Medicine (EMB) is an esteemed international healthcare and medical decision-making journal, dedicated to publishing groundbreaking research outcomes in evidence-based decision-making, research, practice, and education. Serving as the official English-language journal of the Cochrane China Centre and West China Hospital of Sichuan University, we eagerly welcome editorials, commentaries, and systematic reviews encompassing various topics such as clinical trials, policy, drug and patient safety, education, and knowledge translation.
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