{"title":"Cystathionine-<b>β</b>-synthase expression correlates with tumour progression and adverse prognosis in patients with colon cancer.","authors":"Xiao-Jie Hu, Yun Sun, Guang-Jie Liu, Juan Zhang, Li-Xiao Zhang, Yan-Hui Peng","doi":"10.1177/03000605241263726","DOIUrl":null,"url":null,"abstract":"<p><strong>Objective: </strong>To investigate the levels of cystathionine-β-synthase (CBS) in colon cancer tissues compared with adjacent control tissues; and to examine the relationship between CBS level and clinical characteristics and prognosis.</p><p><strong>Methods: </strong>This retrospective study enrolled patients with primary colon cancer. Paraffin-embedded specimens were used to create pathological tissue microarrays. Immunohistochemistry was performed on the microarray to detect the levels of CBS in colon cancer tissues and normal adjacent tissues. Analyses were undertaken to examine the relationship between the level of CBS and clinical characteristics and prognosis.</p><p><strong>Results: </strong>A total of 216 patients (107 males and 109 females) were included in the study. The level of CBS in cancer tissues was found to be significantly increased compared with normal adjacent control tissues. There were significant differences in tumour location, tumour-node-metastasis stage and survival rate between the CBS-negative and CBS-positive groups. Positive CBS immunostaining was associated with decreased survival in colon cancer patients. The results of multivariate Cox regression analysis revealed that tumour location and positive CBS immunostaining were independent prognostic factors for survival.</p><p><strong>Conclusion: </strong>Positive CBS immunostaining was closely associated with colon cancer and high levels of CBS might accelerate tumour development and affect patient prognosis in colon cancer.</p>","PeriodicalId":16129,"journal":{"name":"Journal of International Medical Research","volume":null,"pages":null},"PeriodicalIF":1.4000,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11439173/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of International Medical Research","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1177/03000605241263726","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"MEDICINE, RESEARCH & EXPERIMENTAL","Score":null,"Total":0}
引用次数: 0
Abstract
Objective: To investigate the levels of cystathionine-β-synthase (CBS) in colon cancer tissues compared with adjacent control tissues; and to examine the relationship between CBS level and clinical characteristics and prognosis.
Methods: This retrospective study enrolled patients with primary colon cancer. Paraffin-embedded specimens were used to create pathological tissue microarrays. Immunohistochemistry was performed on the microarray to detect the levels of CBS in colon cancer tissues and normal adjacent tissues. Analyses were undertaken to examine the relationship between the level of CBS and clinical characteristics and prognosis.
Results: A total of 216 patients (107 males and 109 females) were included in the study. The level of CBS in cancer tissues was found to be significantly increased compared with normal adjacent control tissues. There were significant differences in tumour location, tumour-node-metastasis stage and survival rate between the CBS-negative and CBS-positive groups. Positive CBS immunostaining was associated with decreased survival in colon cancer patients. The results of multivariate Cox regression analysis revealed that tumour location and positive CBS immunostaining were independent prognostic factors for survival.
Conclusion: Positive CBS immunostaining was closely associated with colon cancer and high levels of CBS might accelerate tumour development and affect patient prognosis in colon cancer.
目的研究结肠癌组织与邻近对照组织中胱硫醚-β-合成酶（CBS）水平的比较，并探讨CBS水平与临床特征和预后的关系：这项回顾性研究纳入了原发性结肠癌患者。方法：这项回顾性研究纳入了原发性结肠癌患者，使用石蜡包埋标本制作病理组织芯片。对芯片进行免疫组化，检测结肠癌组织和邻近正常组织中的 CBS 水平。研究人员对 CBS 水平与临床特征和预后之间的关系进行了分析：研究共纳入 216 例患者（男 107 例，女 109 例）。研究发现，与邻近的正常对照组织相比，癌症组织中的 CBS 水平明显升高。CBS阴性组和CBS阳性组在肿瘤位置、肿瘤-结节-转移分期和生存率方面存在明显差异。CBS 免疫染色阳性与结肠癌患者生存率下降有关。多变量 Cox 回归分析结果显示，肿瘤位置和 CBS 免疫染色阳性是影响生存率的独立预后因素：结论：CBS 免疫染色阳性与结肠癌密切相关，高水平的 CBS 可能会加速肿瘤的发展并影响结肠癌患者的预后。
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_Journal of International Medical Research_ is a leading international journal for rapid publication of original medical, pre-clinical and clinical research, reviews, preliminary and pilot studies on a page charge basis.
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