Primary Central Nervous System Burkitt's Lymphoma in a Pediatric Patient: A Case Report and Literature Review.

IF 0.9 4区 医学 Q4 HEMATOLOGY Journal of Pediatric Hematology/Oncology Pub Date : 2024-10-01 Epub Date: 2024-09-26 DOI:10.1097/MPH.0000000000002944
Jian Zhao, Mohammad Arian Hassani, Jincheng Song, Xiuhua Sun
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Abstract

Objective: The objective of this research is to examine the therapy and outlook of pediatric primary central nervous system Burkitt lymphomas.

Methods: This study involves a retrospective analysis of the clinical data of a child with primary central nervous system Burkitt lymphoma who underwent treatment in our department. In addition, pertinent literature was reviewed to provide a comprehensive understanding of the topic.

Results: The patient was admitted to the neurosurgery department with symptoms of headache and vomiting. Brain magnetic resonance imaging (MRI) revealed multiple lesions in the right frontal and temporal lobes, dorsal thalamus, and posterior medulla oblongata. Most of the tumor mass was surgically removed from the right ventricle and diagnosed as Burkitt lymphoma. Abnormal lymph nodes were not found outside of the central nervous system. The patient achieved complete remission (CR) after receiving 6 cycles of treatment (R-AA-BB-CC-AA-BB-CC) based on the regimen of the Southern Pediatric Non-Hodgkin Lymphoma Treatment Collaboration Group 2017. As of November 23, 2023, the patient remained alive with no evidence of recurrence.

Conclusions: Primary central nervous system Burkitt lymphoma is rare in children, and there is no universally accepted treatment protocol. However, the regimen outlined by the South China Children's Cancer Group-Non-Hodgkin Lymphoma in 2017 (SCCCG-NHL-2017) can serve as a useful reference for treating pediatric non-Hodgkin lymphoma.

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一名儿童患者的原发性中枢神经系统伯基特淋巴瘤:病例报告与文献综述。
研究目的本研究旨在探讨小儿原发性中枢神经系统伯基特淋巴瘤的治疗和前景:本研究对一名在我科接受治疗的原发性中枢神经系统伯基特淋巴瘤患儿的临床资料进行了回顾性分析。此外,还查阅了相关文献,以全面了解这一主题:患者因头痛和呕吐症状入住神经外科。脑磁共振成像(MRI)显示右侧额叶和颞叶、丘脑背侧和延髓后部有多处病变。手术从右心室切除了大部分肿瘤块,诊断为伯基特淋巴瘤。中枢神经系统外未发现异常淋巴结。根据南方儿科非霍奇金淋巴瘤治疗协作组2017年的治疗方案,患者在接受6个周期的治疗(R-AA-BB-CC-AA-BB-CC)后获得完全缓解(CR)。截至2023年11月23日,患者仍然存活,无复发迹象:原发性中枢神经系统伯基特淋巴瘤在儿童中非常罕见,目前还没有公认的治疗方案。然而,华南儿童癌症协作组-非霍奇金淋巴瘤2017年(SCCCG-NHL-2017)提出的治疗方案可作为治疗小儿非霍奇金淋巴瘤的有益参考。
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来源期刊
CiteScore
1.90
自引率
8.30%
发文量
415
审稿时长
2.5 months
期刊介绍: ​Journal of Pediatric Hematology/Oncology (JPHO) reports on major advances in the diagnosis and treatment of cancer and blood diseases in children. The journal publishes original research, commentaries, historical insights, and clinical and laboratory observations.
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