Clinical outcomes of NBF gel application in managing mucositis associated with xerostomia.

IF 2 Q2 DENTISTRY, ORAL SURGERY & MEDICINE Maxillofacial Plastic and Reconstructive Surgery Pub Date : 2024-09-29 DOI:10.1186/s40902-024-00445-6
György Szabó, Zsolt Németh, Márton Kivovics
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引用次数: 0

Abstract

Background: Xerostomia, or dry mouth, can be a temporary or persistent symptom resulting from various factors, such as medication use, therapeutic radiation, chemotherapy, autoimmune conditions (e.g., Sjögren's syndrome), and hormonal imbalances. Xerostomia often leads to associated mucositis, which significantly impacts patients' quality of life. The nano-bio-fusion (NBF) gingival gel, a gel-type functional toothpaste containing vitamins C, E, propolis, and herbal extracts in a nano-emulsion state, has shown potential in accelerating the healing of oral mucosal lesions.

Methods: A total of 127 patients (102 females, 25 males) with persistent xerostomia were treated from 2018 to 2023. Of these, 32 patients were treated exclusively with NBF Gel, while 95 patients received NBF Gel in combination with other medications, such as pilocarpine. The underlying causes of xerostomia included irradiation and chemotherapy (12 patients), medication (40 patients), hormonal imbalance (28 patients), and Sjögren's syndrome (47 patients). NBF Gel was applied 2-3 times daily to the tongue and oral mucosa. Treatment effectiveness was evaluated through physical examinations and a patient-reported scale ranging from 1 (no improvement) to 10 (complete improvement), focusing on the healing of mucosal lesions rather than saliva production.

Results: Both treatment groups showed significant improvements in the healing of xerostomia-associated mucositis, particularly in severe cases with visible lesions. Patients treated with NBF Gel reported improved symptoms related to mucosal health, while those who received combination therapy also experienced reduced side effects of pilocarpine due to dose reduction. The most substantial improvements were observed in patients with drug-induced and hormonally-caused xerostomia-related mucositis. No adverse side effects from NBF Gel were reported during the study.

Conclusion: NBF gingival gel proved to be beneficial in accelerating the healing of mucositis associated with xerostomia, regardless of the underlying cause, including medication use, radiotherapy, chemotherapy, hormonal imbalances, and Sjögren's syndrome. It presents a promising adjunctive treatment to improve mucosal health and quality of life for patients suffering from xerostomia-associated mucositis.

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应用 NBF 凝胶治疗与口腔干燥症相关的粘膜炎的临床效果。
背景:口腔干燥症或口干可能是一种暂时性或持续性症状,由多种因素引起,如用药、治疗性放疗、化疗、自身免疫性疾病(如斯约格伦综合征)和内分泌失调。口腔干燥症通常会导致相关的粘膜炎,严重影响患者的生活质量。纳米生物融合(NBF)牙龈凝胶是一种凝胶型功能牙膏,在纳米乳液状态下含有维生素 C、E、蜂胶和草药提取物,已显示出加速口腔黏膜病变愈合的潜力:从2018年到2023年,共治疗了127名顽固性口腔溃疡患者(102名女性,25名男性)。其中,32 名患者只接受了 NBF 凝胶治疗,95 名患者接受了 NBF 凝胶与皮洛卡平等其他药物的联合治疗。口腔干燥症的根本原因包括照射和化疗(12 名患者)、药物治疗(40 名患者)、内分泌失调(28 名患者)和斯约格伦综合征(47 名患者)。NBF 凝胶每天在舌头和口腔粘膜上涂抹 2-3 次。治疗效果通过体格检查和患者报告量表进行评估,量表范围从1(无改善)到10(完全改善),重点关注粘膜病变的愈合情况,而不是唾液分泌情况:结果:两个治疗组在口腔干燥症相关粘膜炎的愈合方面都有明显改善,尤其是在有明显病变的严重病例中。接受 NBF 凝胶治疗的患者表示与粘膜健康有关的症状有所改善,而接受联合疗法的患者也因剂量减少而减少了皮洛卡品的副作用。由药物和激素引起的口腔干燥症相关粘膜炎患者的症状改善最为显著。研究期间未发现 NBF 凝胶的不良副作用:结论:事实证明,NBF牙龈凝胶有利于加速与口腔干燥相关的粘膜炎的愈合,无论其根本原因是什么,包括使用药物、放疗、化疗、激素失衡和斯约格伦综合征。它是一种很有前景的辅助治疗方法,可改善口腔干燥症相关粘膜炎患者的粘膜健康和生活质量。
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来源期刊
Maxillofacial Plastic and Reconstructive Surgery
Maxillofacial Plastic and Reconstructive Surgery DENTISTRY, ORAL SURGERY & MEDICINE-
CiteScore
4.30
自引率
13.00%
发文量
37
审稿时长
13 weeks
期刊最新文献
A retrospective epidemiological analysis of maxillofacial fractures at a tertiary referral hospital in istanbul: a seven-year study of 1,757 patients. Egyptian patients with cleft lip: our experience with primary rhinoplasty. Volume changes in the contralateral submandibular gland following unilateral gland excision in oral cancer patients. Clinical outcomes of NBF gel application in managing mucositis associated with xerostomia. Changes in mandibular width and frontal-lower facial profile after orthognathic surgery using sagittal split ramus osteotomy with removal of internal bone interference in patients with class III skeletal malocclusion
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