Follicle-stimulating hormone receptor gene polymorphisms influence Body Mass Index, metabolism, and bone mineral density in postmenopausal women.

IF 2.5 Q3 ENDOCRINOLOGY & METABOLISM Minerva endocrinology Pub Date : 2024-09-30 DOI:10.23736/S2724-6507.24.04177-0
Rossella Cannarella, Agnese Andaloro, Maria A Caruso, Nicolò Musso, Federica Barbagallo, Rosita A Condorelli, Sandro LA Vignera, Aldo E Calogero
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引用次数: 0

Abstract

Background: Covering a significant part of a woman's life, the postmenopausal phase is often associated with the onset of obesity, metabolic dysfunction, osteoporosis, and their most disabling complications. In this context, scant evidence from both preclinical and clinical studies suggests that single nucleotide polymorphisms (SNPs) of the follicle-stimulating hormone receptor (FSHR) gene might be involved in the etiopathogenesis of these conditions, posing them as possible molecular predictors of their development. Therefore, this study aimed to evaluate the role of the FSHR gene SNPs c.2039A>G and c.-29 G>A on Body Mass Index (BMI), metabolic parameters, and bone metabolism in postmenopausal women.

Methods: To achieve this goal, 49 postmenopausal Caucasian women aged from 45 to 80 years and with no factors known to influence metabolism and/or bone mineral density (BMD) were enrolled and assessed for their medical history, medical family history, anthropometric parameters and hormonal, metabolic and lipid profiles, and BMD. Then, they were genotyped for the FSHR gene SNPs c.2039A>G and c.-29G>A. Finally, the resulting data were classified according to woman's genotypes and subjected to statistical analysis.

Results: No significant differences were found between the distributions of most endpoint parameters examined by genotype. However, none of the women with the c.2039A>G FSHR GG gene SNP were affected by obesity and had the highest lumbar BMD z-score within the cohort. Additionally, those with the FSHR c.-29G>A AA genotype had the lowest serum glucose levels.

Conclusions: This preliminary study suggests that the FSHR c.2039A>G GG SNP, which is associated with reduced sensitivity of the FSHR, may have a protective role against obesity, offering further evidence for the possible association among FSH, FSHR polymorphisms, and insulin metabolism.

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卵泡刺激素受体基因多态性影响绝经后妇女的体重指数、新陈代谢和骨矿物质密度。
背景:绝经后阶段是妇女一生中的重要阶段,往往与肥胖、代谢功能障碍、骨质疏松症及其最严重的致残性并发症的发生有关。在这种情况下,临床前和临床研究的少量证据表明,卵泡刺激素受体(FSHR)基因的单核苷酸多态性(SNPs)可能与这些病症的发病机制有关,并可能成为这些病症发生的分子预测因子。因此,本研究旨在评估 FSHR 基因 SNP c.2039A>G 和 c.-29 G>A 对绝经后妇女体重指数(BMI)、代谢参数和骨代谢的影响:为了实现这一目标,研究人员招募了 49 名绝经后的白种女性,她们的年龄在 45 至 80 岁之间,没有已知的影响新陈代谢和/或骨矿物质密度(BMD)的因素,研究人员对她们的病史、家族病史、人体测量参数、激素、新陈代谢和血脂概况以及 BMD 进行了评估。然后,对他们进行 FSHR 基因 SNP c.2039A>G 和 c.-29G>A 的基因分型。最后,根据妇女的基因型对所得数据进行分类,并进行统计分析:结果:大多数终点参数的分布在不同基因型之间没有发现明显差异。但是,具有 c.2039A>G FSHR GG 基因 SNP 的妇女都没有受到肥胖的影响,而且她们的腰椎 BMD z 分数在队列中最高。此外,FSHR c.-29G>A AA 基因型的女性血清葡萄糖水平最低:这项初步研究表明,FSHR c.2039A>G GG SNP 与 FSHR 敏感性降低有关,可能对肥胖具有保护作用,为 FSH、FSHR 多态性和胰岛素代谢之间可能存在的关联提供了进一步的证据。
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146
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