{"title":"Leveraging tardigrade proteins Dsup and CAHS D for enhanced neural protection in neurosurgery and neuroscience.","authors":"Hethesh Chellapandian, Sivakamavalli Jeyachandran","doi":"10.1007/s10143-024-02901-3","DOIUrl":null,"url":null,"abstract":"<p><p>Tardigrades are microscopic organisms known for their remarkable resilience to extreme environmental conditions, including radiation and desiccation. Two key proteins, Dsup (Damage suppressor protein) and CAHS D (Cytoplasmic Abundant Heat Soluble protein D), play crucial roles in this resilience. Dsup protects DNA from radiation-induced damage, while CAHS D stabilizes cellular structures during desiccation by interacting with, but not retaining, water. These unique mechanisms have significant potential applications in neurosurgery and neuroscience. Dsup could inspire the development of protective agents for neural tissues during radiation-based treatments, minimizing collateral damage and improving patient outcomes. Meanwhile, CAHS D's stabilization properties could lead to new neuroprotective strategies, safeguarding brain cells under stress. Together, these tardigrade proteins offer innovative solutions for enhancing neural protection, opening new avenues for treating neurological conditions and improving the safety and efficacy of neurosurgical procedures.</p>","PeriodicalId":19184,"journal":{"name":"Neurosurgical Review","volume":null,"pages":null},"PeriodicalIF":2.5000,"publicationDate":"2024-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Neurosurgical Review","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1007/s10143-024-02901-3","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"CLINICAL NEUROLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
Tardigrades are microscopic organisms known for their remarkable resilience to extreme environmental conditions, including radiation and desiccation. Two key proteins, Dsup (Damage suppressor protein) and CAHS D (Cytoplasmic Abundant Heat Soluble protein D), play crucial roles in this resilience. Dsup protects DNA from radiation-induced damage, while CAHS D stabilizes cellular structures during desiccation by interacting with, but not retaining, water. These unique mechanisms have significant potential applications in neurosurgery and neuroscience. Dsup could inspire the development of protective agents for neural tissues during radiation-based treatments, minimizing collateral damage and improving patient outcomes. Meanwhile, CAHS D's stabilization properties could lead to new neuroprotective strategies, safeguarding brain cells under stress. Together, these tardigrade proteins offer innovative solutions for enhancing neural protection, opening new avenues for treating neurological conditions and improving the safety and efficacy of neurosurgical procedures.
迟发型生物是一种微型生物，以其对极端环境条件（包括辐射和干燥）的卓越适应能力而闻名。两种关键蛋白质--Dsup（损伤抑制蛋白）和 CAHS D（细胞质丰富热溶性蛋白 D）--在这种恢复能力中发挥着至关重要的作用。Dsup 保护 DNA 免受辐射引起的损伤，而 CAHS D 则在干燥过程中通过与水相互作用来稳定细胞结构，但不保留水分。这些独特的机制在神经外科和神经科学领域具有重要的潜在应用价值。Dsup 可以启发人们在放射治疗过程中开发神经组织保护剂，从而最大限度地减少附带损伤，改善患者预后。与此同时，CAHS D 的稳定特性可以开发出新的神经保护策略，在压力下保护脑细胞。总之，这些沙丁鱼蛋白为加强神经保护提供了创新的解决方案，为治疗神经疾病和提高神经外科手术的安全性和有效性开辟了新的途径。
期刊介绍：
The goal of Neurosurgical Review is to provide a forum for comprehensive reviews on current issues in neurosurgery. Each issue contains up to three reviews, reflecting all important aspects of one topic (a disease or a surgical approach). Comments by a panel of experts within the same issue complete the topic. By providing comprehensive coverage of one topic per issue, Neurosurgical Review combines the topicality of professional journals with the indepth treatment of a monograph. Original papers of high quality are also welcome.
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