Quantitative evaluation of Scout Accelerated Motion Estimation and Reduction (SAMER) MPRAGE for morphometric analysis of brain tissue in patients undergoing evaluation for memory loss

IF 4.7 2区 医学 Q1 NEUROIMAGING NeuroImage Pub Date : 2024-09-28 DOI:10.1016/j.neuroimage.2024.120865
Nelson Gil , Azadeh Tabari , Wei-Ching Lo , Bryan Clifford , Min Lang , Komal Awan , Kyla Gaudet , Daniel Nicolas Splitthoff , Daniel Polak , Stephen Cauley , Susie Y. Huang
{"title":"Quantitative evaluation of Scout Accelerated Motion Estimation and Reduction (SAMER) MPRAGE for morphometric analysis of brain tissue in patients undergoing evaluation for memory loss","authors":"Nelson Gil ,&nbsp;Azadeh Tabari ,&nbsp;Wei-Ching Lo ,&nbsp;Bryan Clifford ,&nbsp;Min Lang ,&nbsp;Komal Awan ,&nbsp;Kyla Gaudet ,&nbsp;Daniel Nicolas Splitthoff ,&nbsp;Daniel Polak ,&nbsp;Stephen Cauley ,&nbsp;Susie Y. Huang","doi":"10.1016/j.neuroimage.2024.120865","DOIUrl":null,"url":null,"abstract":"<div><h3>Background</h3><div>Three-dimensional (3D) T1-weighted MRI sequences such as the magnetization prepared rapid gradient echo (MPRAGE) sequence are important for assessing regional cortical atrophy in the clinical evaluation of dementia but have long acquisition times and are prone to motion artifact. The recently developed Scout Accelerated Motion Estimation and Reduction (SAMER) retrospective motion correction method addresses motion artifact within clinically-acceptable computation times and has been validated through qualitative evaluation in inpatient and emergency settings.</div></div><div><h3>Methods</h3><div>We evaluated the quantitative accuracy of morphometric analysis of SAMER motion-corrected compared to non-motion-corrected MPRAGE images by estimating cortical volume and thickness across neuroanatomical regions in two subject groups: (1) healthy volunteers and (2) patients undergoing evaluation for dementia. In part (1), we used a set of 108 MPRAGE reconstructed images derived from 12 healthy volunteers to systematically assess the effectiveness of SAMER in correcting varying degrees of motion corruption, ranging from mild to severe. In part (2), 29 patients who were scheduled for brain MRI with memory loss protocol and had motion corruption on their clinical MPRAGE scans were prospectively enrolled.</div></div><div><h3>Results</h3><div>In part (1), SAMER resulted in effective correction of motion-induced cortical volume and thickness reductions. We observed systematic increases in the estimated cortical volume and thickness across all neuroanatomical regions and a relative reduction in percent error values compared to reference standard scans of up to 66 % for the cerebral white matter volume. In part (2), SAMER resulted in statistically significant volume increases across anatomical regions, with the most pronounced increases seen in the parietal and temporal lobes, and general reductions in percent error relative to reference standard clinical scans.</div></div><div><h3>Conclusion</h3><div>SAMER improves the accuracy of morphometry through systematic increases and recovery of the estimated cortical volume and cortical thickness following motion correction, which may affect the evaluation of regional cortical atrophy in patients undergoing evaluation for dementia.</div></div>","PeriodicalId":19299,"journal":{"name":"NeuroImage","volume":"300 ","pages":"Article 120865"},"PeriodicalIF":4.7000,"publicationDate":"2024-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"NeuroImage","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S1053811924003628","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"NEUROIMAGING","Score":null,"Total":0}
引用次数: 0

Abstract

Background

Three-dimensional (3D) T1-weighted MRI sequences such as the magnetization prepared rapid gradient echo (MPRAGE) sequence are important for assessing regional cortical atrophy in the clinical evaluation of dementia but have long acquisition times and are prone to motion artifact. The recently developed Scout Accelerated Motion Estimation and Reduction (SAMER) retrospective motion correction method addresses motion artifact within clinically-acceptable computation times and has been validated through qualitative evaluation in inpatient and emergency settings.

Methods

We evaluated the quantitative accuracy of morphometric analysis of SAMER motion-corrected compared to non-motion-corrected MPRAGE images by estimating cortical volume and thickness across neuroanatomical regions in two subject groups: (1) healthy volunteers and (2) patients undergoing evaluation for dementia. In part (1), we used a set of 108 MPRAGE reconstructed images derived from 12 healthy volunteers to systematically assess the effectiveness of SAMER in correcting varying degrees of motion corruption, ranging from mild to severe. In part (2), 29 patients who were scheduled for brain MRI with memory loss protocol and had motion corruption on their clinical MPRAGE scans were prospectively enrolled.

Results

In part (1), SAMER resulted in effective correction of motion-induced cortical volume and thickness reductions. We observed systematic increases in the estimated cortical volume and thickness across all neuroanatomical regions and a relative reduction in percent error values compared to reference standard scans of up to 66 % for the cerebral white matter volume. In part (2), SAMER resulted in statistically significant volume increases across anatomical regions, with the most pronounced increases seen in the parietal and temporal lobes, and general reductions in percent error relative to reference standard clinical scans.

Conclusion

SAMER improves the accuracy of morphometry through systematic increases and recovery of the estimated cortical volume and cortical thickness following motion correction, which may affect the evaluation of regional cortical atrophy in patients undergoing evaluation for dementia.
查看原文
分享 分享
微信好友 朋友圈 QQ好友 复制链接
本刊更多论文
定量评估 Scout 加速运动估计和还原 (SAMER) MPRAGE 对接受记忆丧失评估患者脑组织形态计量分析的效果。
背景:三维(3D)T1加权磁共振成像序列(如磁化准备快速梯度回波(MPRAGE)序列)对于评估痴呆症临床评估中的区域皮质萎缩非常重要,但其采集时间较长,容易产生运动伪影。最近开发的Scout加速运动估计和减少(SAMER)回溯运动校正方法在临床可接受的计算时间内解决了运动伪影问题,并通过住院和急诊环境的定性评估得到了验证:我们评估了经 SAMER 运动校正的 MPRAGE 图像与未经运动校正的 MPRAGE 图像的形态计量分析的定量准确性,方法是估算两组受试者神经解剖区域的皮质体积和厚度:(1) 健康志愿者和 (2) 正在接受痴呆评估的患者。在第(1)部分中,我们使用了一组来自 12 名健康志愿者的 108 幅 MPRAGE 重建图像,系统地评估了 SAMER 在校正不同程度(从轻微到严重)运动损伤方面的有效性。在第(2)部分中,我们前瞻性地招募了 29 名计划接受脑部磁共振成像记忆缺失方案检查的患者,这些患者的临床 MPRAGE 扫描图像存在运动损伤:结果:在第(1)部分中,SAMER 能有效校正运动引起的皮质体积和厚度减少。我们观察到所有神经解剖区域的皮质体积和厚度的估计值都有系统性的增加,与参考标准扫描相比,大脑白质体积的百分误差值相对减少了 66%。在第(2)部分中,SAMER 使各解剖区域的体积在统计学上显著增加,顶叶和颞叶的增加最为明显,与参考标准临床扫描相比,误差百分比普遍降低:结论:SAMER 通过系统地增加和恢复运动校正后估计的皮质体积和皮质厚度,提高了形态测量的准确性,这可能会影响对痴呆患者进行区域皮质萎缩评估。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 去求助
来源期刊
NeuroImage
NeuroImage 医学-核医学
CiteScore
11.30
自引率
10.50%
发文量
809
审稿时长
63 days
期刊介绍: NeuroImage, a Journal of Brain Function provides a vehicle for communicating important advances in acquiring, analyzing, and modelling neuroimaging data and in applying these techniques to the study of structure-function and brain-behavior relationships. Though the emphasis is on the macroscopic level of human brain organization, meso-and microscopic neuroimaging across all species will be considered if informative for understanding the aforementioned relationships.
期刊最新文献
Differentiating atypical parkinsonian syndromes with hyperbolic few-shot contrastive learning Exploring the relationship between hallucination proneness and brain morphology Biological mechanism of sex differences in mental rotation: Evidence from multimodal MRI, transcriptomic and receptor/transporter data. Different oscillatory mechanisms of dementia-related diseases with cognitive impairment in closed-eye state. Generative Modeling of the Circle of Willis Using 3D-StyleGAN.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
已复制链接
已复制链接
快去分享给好友吧!
我知道了
×
扫码分享
扫码分享
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1