The association of dietary total antioxidant capacity and gestational diabetes: a prospective cohort study from the Mothers and their children's health (MATCH).

IF 4.6 2区 医学 Q1 ENDOCRINOLOGY & METABOLISM Nutrition & Diabetes Pub Date : 2024-09-27 DOI:10.1038/s41387-024-00333-y
Shilan Heshmati, Jalal Moludi, Seyed Mostafa Nachvak, Reihaneh Pirjani, Javad Heshmati, Mahdi Sepidarkish
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Abstract

Background/objectives: There is evidence to support the hypothesis that a diet rich in antioxidants can help safeguard against the development of gestational diabetes mellitus (GDM). This study aimed to investigate the association between dietary total antioxidant capacity (DTAC) during early pregnancy and the risk of GDM.

Subjects/methods: We included 1856 pregnant women in their first trimester from the Mothers and their Children's Health (MATCH) prospective cohort study. Prepregnancy dietary intake was assessed using a validated food frequency questionnaire (FFQ) and was used to calculate the DTAC score. Incident GDM was diagnosed based on the American Diabetes Association criteria. We estimated the association between DTAC and GDM using propensity score-based inverse probability weighting (IPW).

Results: Overall, 369 (14.6%) of the pregnant women were identified with GDM. The mean DTAC score and the corresponding standard deviation (SD) was 2.82± (2.56) mmol/100 g, with a range of 0.01 to 18.55. The adjusted risk of GDM decreased by 34% (95% CI = 10%, 52%, p = 0.023) for each DTAC score increase. The results showed that women in the highest quartile of DTAC had a lower risk of developing GDM compared to those in the lowest quartile (adjusted RR: 0.29, 95% CI: 0.12, 0.68, p = 0.005).

Conclusion: DTAC in early pregnancy is significantly associated with a lower risk of GDM. Additional larger cohort studies are needed to validate these findings.

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膳食总抗氧化能力与妊娠糖尿病的关系:母亲及其子女健康(MATCH)前瞻性队列研究。
背景/目的:有证据表明,富含抗氧化剂的饮食有助于预防妊娠糖尿病(GDM)的发生。本研究旨在调查孕早期膳食总抗氧化能力(DTAC)与妊娠糖尿病风险之间的关系:我们从母亲及其子女健康(MATCH)前瞻性队列研究中纳入了 1856 名怀孕头三个月的孕妇。使用有效的食物频率问卷(FFQ)评估孕前饮食摄入量,并计算 DTAC 分数。根据美国糖尿病协会的标准诊断为糖尿病并发症。我们使用基于倾向得分的反概率加权法(IPW)估算了 DTAC 与 GDM 之间的关联:结果:总计有 369 名(14.6%)孕妇被确诊为 GDM。DTAC 评分的平均值和相应的标准差(SD)为 2.82± (2.56) mmol/100 g,范围在 0.01 至 18.55 之间。DTAC 评分每增加 1 分,GDM 的调整风险就会降低 34% (95% CI = 10%, 52%, p = 0.023)。结果显示,与最低四分位数的妇女相比,DTAC最高四分位数的妇女发生GDM的风险较低(调整后RR:0.29,95% CI:0.12,0.68,p = 0.005):结论:妊娠早期的 DTAC 与较低的 GDM 风险显著相关。结论:妊娠早期 DTAC 与 GDM 风险的降低有明显关系,需要更多更大规模的队列研究来验证这些发现。
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来源期刊
Nutrition & Diabetes
Nutrition & Diabetes ENDOCRINOLOGY & METABOLISM-NUTRITION & DIETETICS
CiteScore
9.20
自引率
0.00%
发文量
50
审稿时长
>12 weeks
期刊介绍: Nutrition & Diabetes is a peer-reviewed, online, open access journal bringing to the fore outstanding research in the areas of nutrition and chronic disease, including diabetes, from the molecular to the population level.
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