A systematic review of single nucleotide polymorphisms affecting allopurinol pharmacokinetics and serum uric acid level.

IF 1.9 4区医学 Q3 PHARMACOLOGY & PHARMACY Pharmacogenomics Pub Date : 2024-01-01 Epub Date: 2024-09-30 DOI:10.1080/14622416.2024.2403969

Farah Aida A Zairol Azwan, Yi Ying Teo, Nor Asyikin Mohd Tahir, Shamin Mohd Saffian, Mohd Makmor-Bakry, Mohd Shahrir Mohamed Said

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Abstract

Aim: To summarize the effects of single nucleotide polymorphisms (SNPs) on the pharmacokinetics of allopurinol to control uric acid levels.Methods: A comprehensive search was conducted in PubMed, Web of Science and Scopus databases from inception to January 2024, includes 17 articles focusing on SNPs and pharmacokinetics of allopurinol and oxypurinol.Results: A total of 11 SNPs showed a significant association with pharmacokinetics of allopurinol and oxypurinol, as well as their potential clinical implications.Conclusion: SNPs in ATP-binding cassette super-family G member 2 (ABCG2), solute carrier family 2 member 9 (SLC2A9), solute carrier family 17 member 1 (SLC17A1), solute carrier family 22 member 12 (SLC22A12), solute carrier family 22 member 13 (SLC22A13) and PDZ domain containing 1 (PDZK1) genes were associated with allopurinol clearance, while SNPs in aldehyde oxidase 1 (AOX1) genes involved in metabolism of allopurinol. SNPs in gremlin 2, DAN family BMP antagonist (GREM2) gene impacted uric acid control, but the specific mechanism governing the expression of GREM2 remains unknown. Our study indicated that the identified SNPs show contradictory effects, reflecting inconsistencies and differences observed across various studies.

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影响别嘌醇药代动力学和血清尿酸水平的单核苷酸多态性系统综述。

目的：总结单核苷酸多态性（SNPs）对控制尿酸水平的别嘌醇药代动力学的影响：方法：在PubMed、Web of Science和Scopus数据库中进行了全面检索，从开始到2024年1月，包括17篇关于SNPs与别嘌醇和奥昔嘌醇药代动力学的文章：结果：共有11个SNPs与别嘌呤醇和奥昔嘌呤醇的药代动力学及其潜在的临床意义有显著关联：溶质运载家族 22 成员 13 (SLC22A13) 和 PDZ domain containing 1 (PDZK1) 基因中的 SNP 与别嘌醇清除率相关，而醛氧化酶 1 (AOX1) 基因中的 SNP 则参与别嘌醇的代谢。格雷姆林 2、DAN 家族 BMP 拮抗剂（GREM2）基因中的 SNP 影响尿酸的控制，但 GREM2 表达的具体机制仍不清楚。我们的研究表明，已确定的 SNPs 显示出相互矛盾的影响，反映了不同研究中观察到的不一致和差异。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Pharmacogenomics 医学-药学

CiteScore

3.40

自引率

9.50%

发文量

审稿时长

4-8 weeks

期刊介绍： Pharmacogenomics (ISSN 1462-2416) is a peer-reviewed journal presenting reviews and reports by the researchers and decision-makers closely involved in this rapidly developing area. Key objectives are to provide the community with an essential resource for keeping abreast of the latest developments in all areas of this exciting field. Pharmacogenomics is the leading source of commentary and analysis, bringing you the highest quality expert analyses from corporate and academic opinion leaders in the field.