Sickle Cell Disease and Lead Poisoning in New York City, 2005-2019.

IF 6.2 2区医学 Q1 PEDIATRICS Pediatrics Pub Date : 2024-10-01 DOI:10.1542/peds.2024-067808G

Leah Seifu, Slavenka Sedlar, Ta'Sharee Grant, Andrew Faciano, Jacqueline Ehrlich

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Abstract

Objectives: Previous analyses of New York City (NYC) health department's lead registry indicated that, among children with lead poisoning, an increased prevalence of sickle cell disease (SCD) exists. However, SCD is not considered a risk factor for lead poisoning. We assessed the association between SCD and childhood lead poisoning to determine if specific lead poisoning prevention efforts are needed for children with SCD.

Methods: We analyzed NYC's lead registry data for children with venous blood lead levels (BLLs) ≥15 mcg/dL during 2005 to 2019. t tests and χ2 tests were performed to compare demographic characteristics, BLLs, and lead exposure risks in non-Hispanic Black children with and without SCD. A t test was used to compare observed SCD prevalence among Black children with BLLs ≥15 mcg/dL with an estimated 0.43% SCD prevalence among Black NYC children.

Results: Among 1728 Black children with BLLs ≥15 mcg/dL identified, 37 (2.14%) had SCD. When comparing children with and without SCD, both mean age at peak BLL (62.8 versus 42.7 months; P = .003) and peak BLL (42.59 versus 23.06 mcg/dL; P = .008) were higher for children with SCD. Among risk factors for lead exposure, children with SCD had higher prevalence of pica. Observed SCD prevalence was 1.71% higher than estimated SCD prevalence among Black NYC children (P < .001).

Conclusions: We found a potential association between SCD and childhood lead poisoning. Pica emerged as a potentially important risk factor. Our findings might have implications for lead poisoning prevention guidelines for children with SCD.

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2005-2019 年纽约市镰状细胞病和铅中毒情况。

目的：之前对纽约市（NYC）卫生部门的铅登记簿进行的分析表明，在铅中毒儿童中，镰状细胞病（SCD）的发病率有所增加。然而，SCD 并不被认为是铅中毒的危险因素。我们评估了 SCD 与儿童铅中毒之间的关联，以确定是否需要针对 SCD 儿童开展特定的铅中毒预防工作：我们分析了纽约市 2005 年至 2019 年期间静脉血铅含量（BLLs）≥15 mcg/dL 的儿童铅登记数据。对患有和未患有 SCD 的非西班牙裔黑人儿童的人口统计学特征、BLLs 和铅暴露风险进行了 t 检验和 χ2 检验。用 t 检验比较了 BLL≥15 mcg/dL 的黑人儿童中观察到的 SCD 患病率与纽约市黑人儿童中估计的 0.43% 的 SCD 患病率：在 1728 名 BLL≥15 mcg/dL 的黑人儿童中，有 37 人（2.14%）患有 SCD。将患有和未患有 SCD 的儿童进行比较，SCD 儿童的铅含量峰值平均年龄（62.8 个月对 42.7 个月；P = .003）和铅含量峰值（42.59 微克/分升对 23.06 微克/分升；P = .008）均较高。在铅暴露的风险因素中，SCD 患儿的 pica 患病率较高。在纽约市黑人儿童中，观察到的 SCD 患病率比估计的 SCD 患病率高 1.71%（P < .001）：我们发现 SCD 与儿童铅中毒之间存在潜在联系。Pica是一个潜在的重要风险因素。我们的发现可能会对 SCD 儿童铅中毒预防指南产生影响。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Pediatrics 医学-小儿科

CiteScore

12.80

自引率

5.00%

发文量

791

审稿时长

2-3 weeks

期刊介绍： The Pediatrics® journal is the official flagship journal of the American Academy of Pediatrics (AAP). It is widely cited in the field of pediatric medicine and is recognized as the leading journal in the field. The journal publishes original research and evidence-based articles, which provide authoritative information to help readers stay up-to-date with the latest developments in pediatric medicine. The content is peer-reviewed and undergoes rigorous evaluation to ensure its quality and reliability. Pediatrics also serves as a valuable resource for conducting new research studies and supporting education and training activities in the field of pediatrics. It aims to enhance the quality of pediatric outpatient and inpatient care by disseminating valuable knowledge and insights. As of 2023, Pediatrics has an impressive Journal Impact Factor (IF) Score of 8.0. The IF is a measure of a journal's influence and importance in the scientific community, with higher scores indicating a greater impact. This score reflects the significance and reach of the research published in Pediatrics, further establishing its prominence in the field of pediatric medicine.