Syed Mohammed Basheeruddin Asdaq, Abdulaziz Ali Almutiri, Abdullah Alenzi, Maheen Shaikh, Mujeeb Ahmed Shaik, Sultan Alshehri, Syed Imam Rabbani
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引用次数: 0
Abstract
Background: Neurodegenerative diseases primarily afflict the elderly and are characterized by a progressive loss of neurons. Oxidative stress is intricately linked to the advancement of these conditions. This study focuses on Phoenix dactylifera (P. dactylifera; Family: Arecaceae), commonly known as "Ajwa," a globally cultivated herbal plant renowned for its potent antioxidant properties and reported neuroprotective effects in pharmacological studies. Method: This comprehensive systematic review delves into the antioxidant properties of plant extracts and their phytochemical components, with a particular emphasis on P. dactylifera and its potential neuroprotective benefits. Preferred reporting items for systemic reviews and meta-analysis (PRISMA) were employed to review the articles. Results: The study includes 269 articles published in the literature and 17 were selected after qualitative analysis. The growing body of research underscores the critical role of polyphenolic compounds found in P. dactylifera, which significantly contribute to its neuroprotective effects through antioxidant mechanisms. Despite emerging insights into the antioxidant actions of P. dactylifera, further investigation is essential to fully elucidate the specific pathways through which it confers neuroprotection. Conclusions: Like many other plant-based supplements, P. dactylifera's antioxidant effects are likely mediated by synergistic interactions among its diverse bioactive compounds, rather than by any single constituent alone. Therefore, additional preclinical and clinical studies are necessary to explore P. dactylifera's therapeutic potential comprehensively, especially in terms of its targeted antioxidant activities aimed at mitigating neurodegenerative processes. Such research holds promise for advancing our understanding and potentially harnessing the therapeutic benefits of P. dactylifera in neuroprotection.
背景:神经退行性疾病主要困扰老年人,其特征是神经元的逐渐丧失。氧化应激与这些疾病的发展有着错综复杂的联系。本研究的重点是凤凰木(Phoenix dactylifera;科:Arecaceae),俗称 "Ajwa",这是一种全球栽培的草本植物,因其强大的抗氧化特性而闻名,药理研究报告称其具有神经保护作用。研究方法这篇全面的系统综述深入探讨了植物提取物及其植物化学成分的抗氧化特性,特别强调了 P. dactylifera 及其潜在的神经保护作用。文章采用了系统综述和荟萃分析的首选报告项目(PRISMA)进行综述。结果:研究包括 269 篇发表在文献中的文章,经过定性分析筛选出 17 篇。越来越多的研究强调了在 P. dactylifera 中发现的多酚化合物的关键作用,这些化合物通过抗氧化机制大大促进了其神经保护作用。尽管人们对 P. dactylifera 的抗氧化作用有了新的认识,但要充分阐明其保护神经的具体途径,还需要进一步的研究。结论:与许多其他植物性补充剂一样,P. dactylifera 的抗氧化作用可能是由其多种生物活性化合物之间的协同作用而非任何单一成分单独起作用的。因此,有必要进行更多的临床前和临床研究,以全面探索 P. dactylifera 的治疗潜力,尤其是其旨在缓解神经退行性过程的靶向抗氧化活性。此类研究有望促进我们对 P. dactylifera 的了解,并有可能利用其在神经保护方面的治疗功效。