Therapeutic implications of homologous repair deficiency testing in patients with prostate cancer (Part 2 of 2).

IF 5.1 2区医学 Q1 ONCOLOGY Prostate Cancer and Prostatic Diseases Pub Date : 2024-09-27 DOI:10.1038/s41391-024-00887-z

Anthony V Serritella, Amy Taylor, Michael C Haffner, Wassim Abida, Alan Bryce, Lawrence I Karsh, Scott T Tagawa, Przemyslaw Twardowski, Andrew J Armstrong, Joshua M Lang

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Abstract

Background/objectives: Unfortunately, not all metastatic castration-resistant prostate cancer (mCRPC) patients receive available life-prolonging systemic therapies, emphasizing the need to optimize mCRPC treatment selections. Better guidelines are necessary to determine genetic testing for prostate cancer.

Subjects/methods: In this two-part expert opinion-based guide, we provide an expert consensus opinion on the utilization of germline and somatic testing to detect HRR alterations in patients with mCRPC. This guide was developed by a multidisciplinary expert panel that convened in 2023-2024, including representatives from medical oncology, urology, radiation oncology, pathology, medical genomics, and basic science.

Results/conclusions: In this second part, we highlight how genetic testing can lead to improved, life-prolonging mCRPC therapeutic strategies based on a review of the recent phase III trials and subsequent regulatory approvals for PARP inhibitors in mCRPC.

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前列腺癌患者同源修复缺陷检测的治疗意义（第 2 部分，共 2 部分）。

背景/目的：遗憾的是，并非所有转移性抗性前列腺癌（mCRPC）患者都能接受可延长生命的系统性疗法，这就强调了优化mCRPC治疗选择的必要性。有必要制定更好的指南来确定前列腺癌的基因检测：在这份由两部分组成、基于专家意见的指南中，我们就利用种系和体细胞检测来检测mCRPC患者的HRR改变提供了专家共识意见。本指南由2023-2024年召集的多学科专家小组制定，专家小组成员包括来自肿瘤内科、泌尿外科、放射肿瘤科、病理科、医学基因组学和基础科学的代表：在第二部分中，我们将在回顾最近的III期试验以及随后监管部门批准的PARP抑制剂治疗mCRPC的基础上，重点介绍基因检测如何能够改进mCRPC的治疗策略，延长患者的生命。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Prostate Cancer and Prostatic Diseases 医学-泌尿学与肾脏学

CiteScore

10.00

自引率

6.20%

发文量

142

审稿时长

6-12 weeks

期刊介绍： Prostate Cancer and Prostatic Diseases covers all aspects of prostatic diseases, in particular prostate cancer, the subject of intensive basic and clinical research world-wide. The journal also reports on exciting new developments being made in diagnosis, surgery, radiotherapy, drug discovery and medical management. Prostate Cancer and Prostatic Diseases is of interest to surgeons, oncologists and clinicians treating patients and to those involved in research into diseases of the prostate. The journal covers the three main areas - prostate cancer, male LUTS and prostatitis. Prostate Cancer and Prostatic Diseases publishes original research articles, reviews, topical comment and critical appraisals of scientific meetings and the latest books. The journal also contains a calendar of forthcoming scientific meetings. The Editors and a distinguished Editorial Board ensure that submitted articles receive fast and efficient attention and are refereed to the highest possible scientific standard. A fast track system is available for topical articles of particular significance.