Bone-targeting engineered milk-derived extracellular vesicles for MRI-assisted therapy of osteoporosis.

IF 5.6 1区医学 Q1 MATERIALS SCIENCE, BIOMATERIALS Regenerative Biomaterials Pub Date : 2024-09-13 eCollection Date: 2024-01-01 DOI:10.1093/rb/rbae112

Qing Huang, Yang Jiang, Yang Cao, Yunchuan Ding, Jinghui Cai, Tingqian Yang, Xin Zhou, Qiang Wu, Danyang Li, Qingyu Liu, Fangping Li

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引用次数: 0

Abstract

The imbalance between osteoblasts and osteoclasts is the cause of osteoporosis. Milk-derived extracellular vesicles (mEVs), excellent drug delivery nanocarriers, can promote bone formation and inhibit bone resorption. In this study, we conjugated bone-targeting peptide (AspSerSer, DSS)₆ to mEVs by click chemistry and then loaded with SRT2104, a SIRT1 (silent mating-type information regulation 2 homolog 1) agonist that was proofed to help reduce bone loss. The engineered (DSS)₆-mEV-SRT2104 had the intrinsic anti-osteoporosis function of mEVs and SRT2104 to reverse the imbalance in bone homeostasis by simultaneously regulating osteogenesis and osteoclastogenesis. Furthermore, we labelled mEVs with MnB nanoparticles that can be used for the in vivo magnetic resonance imaging (MRI) visualization. The obtained nanocomposites significantly prevented bone loss in osteoporosis mice and increased bone mineral density, exhibiting superior bone accumulation under MRI. We believe the proposed (DSS)₆-mEV-SRT2104/MnB provides a novel paradigm for osteoporosis treatment and monitoring.

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用于核磁共振成像辅助治疗骨质疏松症的骨靶向工程乳源性细胞外囊泡。

成骨细胞和破骨细胞之间的失衡是导致骨质疏松症的原因。牛奶衍生的细胞外囊泡（mEVs）是一种优良的纳米药物载体，可促进骨形成并抑制骨吸收。在这项研究中，我们通过点击化学将骨靶向肽（AspSerSer，DSS）6与mEVs共轭，然后载入SRT2104，SRT2104是一种SIRT1（沉默交配型信息调节2同源物1）激动剂，经证实有助于减少骨质流失。工程（DSS）6-mEV-SRT2104 具有 mEVs 和 SRT2104 的内在抗骨质疏松症功能，可通过同时调节成骨和破骨细胞生成来逆转骨平衡失调。此外，我们还在 mEVs 上标记了 MnB 纳米颗粒，可用于体内磁共振成像（MRI）显像。所获得的纳米复合材料能明显防止骨质疏松症小鼠的骨质流失，增加骨矿物质密度，并在核磁共振成像（MRI）下表现出卓越的骨积累能力。我们相信，所提出的 (DSS)6-mEV-SRT2104/MnB 为骨质疏松症的治疗和监测提供了一种新的范例。

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来源期刊

Regenerative Biomaterials Materials Science-Biomaterials

CiteScore

7.90

自引率

16.40%

发文量

审稿时长

10 weeks

期刊介绍： Regenerative Biomaterials is an international, interdisciplinary, peer-reviewed journal publishing the latest advances in biomaterials and regenerative medicine. The journal provides a forum for the publication of original research papers, reviews, clinical case reports, and commentaries on the topics relevant to the development of advanced regenerative biomaterials concerning novel regenerative technologies and therapeutic approaches for the regeneration and repair of damaged tissues and organs. The interactions of biomaterials with cells and tissue, especially with stem cells, will be of particular focus.